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===Environmental contamination=== A major pathway of induced health effects arises from spills or leaks of solvents, especially [[Organochlorine chemistry|chlorinated solvents]], that reach the underlying soil. Since solvents readily migrate substantial distances, the creation of widespread [[soil contamination]] is not uncommon; this is particularly a health risk if [[aquifer]]s are affected.<ref>{{Cite journal |last1=Matteucci |first1=Federica |last2=Ercole |first2=Claudia |last3=del Gallo |first3=Maddalena |date=2015 |title=A study of chlorinated solvent contamination of the aquifers of an industrial area in central Italy: a possibility of bioremediation |journal=Frontiers in Microbiology |volume=6 |page=924 |doi=10.3389/fmicb.2015.00924 |pmid=26388862 |pmc=4556989 |issn=1664-302X |doi-access=free }}</ref> [[Vapor intrusion]] can occur from sites with extensive subsurface solvent contamination.<ref>{{cite journal | vauthors = Forand SP, Lewis-Michl EL, Gomez MI | title = Adverse birth outcomes and maternal exposure to trichloroethylene and tetrachloroethylene through soil vapor intrusion in New York State | journal = Environmental Health Perspectives | volume = 120 | issue = 4 | pages = 616β21 | date = April 2012 | pmid = 22142966 | pmc = 3339451 | doi = 10.1289/ehp.1103884 }}</ref>
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