Editing Vitamin C (section)

===Scurvy===
{{Main|Scurvy}}

[[Scurvy]] is a disease resulting from a deficiency of vitamin C. Without this vitamin, [[collagen]] made by the body is too unstable to perform its function and several other [[enzyme]]s in the body do not operate correctly. Early symptoms are malaise and lethargy, progressing to shortness of breath, bone pain and susceptibility to bruising. As the disease progressed, it is characterized by [[Hyperkeratosis|spots]] on and [[Ecchymosis|bleeding]] under the skin and bleeding gums. The skin lesions are most abundant on the thighs and legs. A person with the ailment looks pale, feels depressed, and is partially immobilized. In advanced scurvy there is fever, old wounds may become open and  [[suppuration|suppurating]], loss of [[Tooth|teeth]], convulsions and, eventually, death. Until quite late in the disease the damage is reversible, as healthy collagen replaces the defective collagen with vitamin{{nbsp}}C repletion.<ref name=lpi2018 /><ref name=AHFS2016 /><ref name="pmid21402244">{{cite journal | vauthors = Magiorkinis E, Beloukas A, Diamantis A | title = Scurvy: past, present and future. | journal = The European Journal of Internal Medicine | volume = 22 | issue = 2 | pages = 147–52 | date = April 2011 | pmid = 21402244 | doi = 10.1016/j.ejim.2010.10.006}}</ref>

Notable human dietary studies of experimentally induced scurvy were conducted on [[conscientious objector]]s during World War II in Britain and on Iowa state prisoners in the late 1960s to the 1980s. Men in the prison study developed the first signs of scurvy about four weeks after starting the vitamin C-free diet, whereas in the earlier British study, six to eight months were required, possibly due to the pre-loading of this group with a 70&nbsp;mg/day supplement for six weeks before the scorbutic diet was fed. Men in both studies had blood levels of ascorbic acid too low to be accurately measured by the time they developed signs of scurvy. These studies both reported that all obvious symptoms of scurvy could be completely reversed by supplementation of only 10&nbsp;mg a day.<ref name="pmid4977512">{{cite journal | vauthors = Hodges RE, Baker EM, Hood J, Sauberlich HE, March SC | title = Experimental scurvy in man | journal = The American Journal of Clinical Nutrition | volume = 22 | issue = 5 | pages = 535–48 | date = May 1969 | pmid = 4977512 | doi = 10.1093/ajcn/22.5.535}}</ref><ref name="pmid16510534">{{cite journal | vauthors = Pemberton J | title = Medical experiments carried out in Sheffield on conscientious objectors to military service during the 1939-45 war | journal = International Journal of Epidemiology | volume = 35 | issue = 3 | pages = 556–8 | date = June 2006 | pmid = 16510534 | doi = 10.1093/ije/dyl020 | doi-access = free | title-link = doi }}</ref> Treatment of scurvy can be with vitamin{{nbsp}}C-containing foods or dietary supplements or injection.<ref name=AHFS2016/><ref name="DRItext" />{{rp|page=101}}