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====Antiandrogens==== [[Antiandrogen]]s are used in more extreme cases.<ref name="assumpcao2014"/> Similar to physical [[castration]], they work by reducing [[androgen]] levels, and have thus been described as [[chemical castration]].<ref name="assumpcao2014"/> The antiandrogen [[cyproterone acetate]] has been shown to substantially reduce sexual fantasies and offending behaviors.<ref name="assumpcao2014"/> [[Medroxyprogesterone acetate]] and [[gonadotropin-releasing hormone agonist]]s (such as [[leuprorelin]]) have also been used to lower sex drive.<ref name="assumpcao2014"/> Due to the side effects, the World Federation of Societies of Biological Psychiatry recommends that hormonal treatments only be used when there is a serious risk of sexual violence, or when other methods have failed.<!-- p. 647 --><ref name="thibaut2010">{{cite journal|vauthors=Thibaut F, De La Barra F, Gordon H, Cosyns P, Bradford JM|title=The World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the biological treatment of paraphilias|journal=The World Journal of Biological Psychiatry|volume=11|issue=4|pages=604β655|year=2010|pmid=20459370|doi=10.3109/15622971003671628|s2cid=14949511}}</ref> Surgical [[castration]] has largely been abandoned because these pharmacological alternatives are similarly effective and less invasive.<ref>{{cite book|first=Michael C.|last=Seto|authorlink=Michael C. Seto|date=2008|title=Sexual Deviance: Theory, Assessment, and Treatment|edition=2nd|publisher=[[The Guilford Press]]|location=New York City|pages=199β200|chapter=Pedophilia: Assessment and Treatment|editor1-first=D. Richard|editor1-last=Laws|editor2-first=William T.|editor2-last=O'Donohue}}</ref>
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