Editing Mouthwash (section)

===Sanguinarine===
[[Sanguinarine]]-containing mouthwashes are marketed as anti-plaque and anti-malodor treatments.<ref name=Scully2013 /> Sanguinarine is a toxic alkaloid herbal extract, obtained from plants such as ''[[Sanguinaria canadensis]]'' (bloodroot), ''[[Argemone mexicana]]'' (Mexican prickly poppy), and others.<ref name=Scully2013 /> However, its use is strongly associated with the development of [[leukoplakia]] (a white patch in the mouth), usually in the buccal sulcus.<ref name=Scully2013 /><ref>[http://www.aaomp.org/public/docs/leukoplakia.pdf Leukoplakia] {{webarchive|url=https://web.archive.org/web/20130703162903/http://www.aaomp.org/public/docs/leukoplakia.pdf |date=3 July 2013 }}, (pdf format) hosted by the American Academy of Oral and Maxillofacial Pathology.  Page accessed on 19 December 2006.</ref> This type of leukoplakia has been termed "sanguinaria-associated keratosis", and more than 80% of people with leukoplakia in the [[vestibule of the mouth]] have used this substance. Upon stopping contact with the causative substance, the lesions may persist for years. Although this type of leukoplakia may show [[dysplasia]], the potential for [[malignancy|malignant]] transformation is unknown.<ref name=Neville2002>{{cite book | vauthors = Neville BW, Damm DD, Allen CM, Bouquot JE |title=Oral & maxillofacial pathology|year=2002|publisher=W.B. Saunders|location=Philadelphia|isbn=978-0721690032|pages=337–345|edition=2nd}}</ref> Ironically, elements within the complementary and alternative medicine industry promote the use of sanguinaria as a therapy for cancer.