Editing Microtubule (section)

===Gene regulation===
The cellular cytoskeleton is a dynamic system that functions on many different levels: In addition to giving the cell a particular form and supporting the transport of vesicles and organelles, it can also influence [[gene expression]]. The [[signal transduction]] mechanisms involved in this communication are little understood. However, the relationship between the drug-mediated depolymerization of microtubules, and the specific expression of [[transcription factors]] has been described, which has provided information on the differential expression of the genes depending on the presence of these factors.<ref name="Rosette1995">{{Cite journal |vauthors=Rosette C, Karin M |date=March 1995 |title=Cytoskeletal control of gene expression: depolymerization of microtubules activates NF-kappa B |journal=The Journal of Cell Biology |volume=128 |issue=6 |pages=1111–9 |doi=10.1083/jcb.128.6.1111 |pmc=2120413 |pmid=7896875}}</ref> This communication between the cytoskeleton and the regulation of the cellular response is also related to the action of [[growth factor]]s: for example, this relation exists for [[CTGF|connective tissue growth factor]].<ref name="Ott2003">{{Cite journal |vauthors=Ott C, Iwanciw D, Graness A, Giehl K, Goppelt-Struebe M |date=November 2003 |title=Modulation of the expression of connective tissue growth factor by alterations of the cytoskeleton |journal=The Journal of Biological Chemistry |volume=278 |issue=45 |pages=44305–11 |doi=10.1074/jbc.M309140200 |pmid=12951326 |doi-access=free}}</ref>