Editing Methadone (section)

=== United States and Canada ===
Methadone is a [[Controlled Drugs and Substances Act|Schedule I]] controlled substance in Canada and Schedule II in the United States, with an ACSCN of 9250 and a 2014 annual aggregate manufacturing quota of 31,875 kilos for sale. [[Methadone intermediate]] is also controlled, under [[ACSCN]] 9226 also under Schedule II, with a quota of 38,875 kilos. In most countries of the world, methadone is similarly restricted. The salts of methadone in use are the hydrobromide (free base conversion ratio 0.793), hydrochloride (0.894), and HCl monohydrate (0.850).<ref>{{cite web |url=http://www.deadiversion.usdoj.gov/quotas/conv_factor/index.html |title=DEA Diversion Control Division |access-date=28 February 2016 |url-status=live |archive-url=https://web.archive.org/web/20160302162948/http://deadiversion.usdoj.gov/quotas/conv_factor/index.html |archive-date=2 March 2016 }}</ref> Methadone is also regulated internationally as a Schedule I controlled substance under the United Nations Single Convention on Narcotic Drugs of 1961.<ref>{{cite web |url=http://www.deadiversion.usdoj.gov/fed_regs/quotas/2014/fr0825.htm |title=DEA Diversion Control Division |access-date=28 February 2016 |url-status=live |archive-url=https://web.archive.org/web/20160304053357/http://www.deadiversion.usdoj.gov/fed_regs/quotas/2014/fr0825.htm |archive-date=4 March 2016 }}</ref><ref name="Nordegren2002">{{cite book | vauthors = Nordegren T | title = The A-Z Encyclopedia of Alcohol and Drug Abuse | url = https://books.google.com/books?id=4yaGePenGKgC&pg=PA366 | access-date = 16 May 2012 | date = 1 March 2002 | publisher = Universal-Publishers | isbn = 978-1-58112-404-0 | page = 366 | url-status = live | archive-url = https://web.archive.org/web/20140101085353/http://books.google.com/books?id=4yaGePenGKgC&pg=PA366 | archive-date = 1 January 2014 }}</ref>

==== Methadone clinics ====
In the United States, prescription of methadone requires intensive monitoring and must be obtained in-person from an Opioid Treatment Program—colloquially known as a 'methadone clinic'—when prescribed for [[opioid use disorder]] (OUD).<ref name="Anderson_2000"/> According to federal laws, methadone cannot be prescribed by a doctor and obtained from a pharmacy to treat addiction. Because of its long half-life, methadone is almost invariably prescribed to be taken in a single daily dose. At nearly all methadone clinics in the US, patients must visit a clinic to receive and take their dose under the supervision of a nurse. Both patients who are new to methadone treatment and high-risk patients—such as those who are using drugs and alcohol, including cannabis in some states—must visit the clinic daily.<ref>{{cite web|title=Methadone|url=https://www.samhsa.gov/medication-assisted-treatment/medications-counseling-related-conditions/methadone|access-date=15 February 2021|website=www.samhsa.gov|date=16 June 2015 |language=en}}</ref><ref>{{cite web|title=42 CFR § 8.12 – Federal opioid treatment standards.|url=https://www.law.cornell.edu/cfr/text/42/8.12|access-date=15 February 2021|website=LII / Legal Information Institute|language=en}}</ref>