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====Pregnancy==== During pregnancy, DHEA-S is [[metabolism|metabolized]] into the sulfates of [[16Ξ±-hydroxy-DHEA]] and [[15Ξ±-hydroxy-DHEA]] in the [[fetus|fetal]] [[liver]] as [[metabolic intermediate|intermediate]]s in the production of the estrogens [[estriol]] and [[estetrol]], respectively.<ref>{{Cite journal |last1=Zbella |first1=E. A. |last2=Ilekis |first2=J. |last3=Scommegna |first3=A. |last4=Benveniste |first4=R. |title=Competitive studies with dehydroepiandrosterone sulfate and 16 alpha-hydroxydehydroepiandrosterone sulfate in cultured human choriocarcinoma JEG-3 cells: effect on estrone, 17 beta-estradiol, and estriol secretion |url=https://pubmed.ncbi.nlm.nih.gov/2942557/ |journal=The Journal of Clinical Endocrinology and Metabolism |year=1986 |volume=63 |issue=3 |pages=751β757 |doi=10.1210/jcem-63-3-751 |issn=0021-972X |pmid=2942557}}</ref>
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