Editing Bone (section)

===Cancer===
{{main|Bone metastases}}
[[Cancer]] can arise in bone tissue, and bones are also a common site for other cancers to spread ([[metastasise]]) to.{{sfn|Davidson|2010|p=1125}} Cancers that arise in bone are called "primary" cancers, although such cancers are rare.{{sfn|Davidson|2010|p=1125}} Metastases within bone are "secondary" cancers, with the most common being [[breast cancer]], [[lung cancer]], [[prostate cancer]], [[thyroid cancer]], and [[kidney cancer]].{{sfn|Davidson|2010|p=1125}} Secondary cancers that affect bone can either destroy bone (called a "[[lytic cycle|lytic]]" cancer) or create bone (a "[[sclerosis (medicine)|sclerotic]]" cancer). Cancers of the bone marrow inside the bone can also affect bone tissue, examples including [[leukemia]] and [[multiple myeloma]]. Bone may also be affected by cancers in other parts of the body. Cancers in other parts of the body may release [[parathyroid hormone]] or [[parathyroid hormone-related peptide]]. This increases bone reabsorption, and can lead to bone fractures.

Bone tissue that is destroyed or altered as a result of cancers is distorted, weakened, and more prone to fracture. This may lead to compression of the [[spinal cord]], destruction of the marrow resulting in [[bruising]], [[bleeding]] and [[immunosuppression]], and is one cause of bone pain. If the cancer is metastatic, then there might be other symptoms depending on the site of the original cancer. Some bone cancers can also be felt.

Cancers of the bone are managed according to their type, their [[cancer staging|stage]], prognosis, and what symptoms they cause. Many primary cancers of bone are treated with [[radiotherapy]]. Cancers of bone marrow may be treated with [[chemotherapy]], and other forms of targeted therapy such as [[immunotherapy]] may be used.{{sfn|Davidson|2010|p=1032}} [[Palliative care]], which focuses on maximising a person's [[quality of life]], may play a role in management, particularly if the likelihood of [[5-year survival|survival within five years]] is poor.