Editing Zinc (section)

====Gastroenteritis====
Zinc is an inexpensive and effective part of treatment of [[diarrhea]] among children in the developing world. Zinc becomes depleted in the body during diarrhea and replenishing zinc with a 10- to 14-day course of treatment can reduce the duration and severity of diarrheal episodes and may also prevent future episodes for as long as three months.<ref>{{cite journal|title=Therapeutic effects of oral zinc in acute and persistent diarrhea in children in developing countries: pooled analysis of randomized controlled trials|pmid=11101480|date=2000|vauthors=Bhutta ZA, Bird SM, Black RE, Brown KH, Gardner JM, Hidayat A, Khatun F, Martorell R, Ninh NX, Penny ME, Rosado JL, Roy SK, Ruel M, Sazawal S, Shankar A<!--|collaboration=The Zinc Investigators’ Collaborative Group-->|display-authors=8|volume=72|issue=6 |pages=1516–1522|journal=The American Journal of Clinical Nutrition |doi=10.1093/ajcn/72.6.1516|doi-access=free}}</ref> [[Gastroenteritis]] is strongly attenuated by ingestion of zinc, possibly by direct antimicrobial action of the ions in the [[gastrointestinal tract]], or by the absorption of the zinc and re-release from immune cells (all [[granulocyte]]s secrete zinc), or both.<ref>{{cite journal|last=Aydemir |first=T. B.|author2=Blanchard, R. K. |author3=Cousins, R. J. |date=2006|title=Zinc supplementation of young men alters metallothionein, zinc transporter, and cytokine gene expression in leukocyte populations |journal=PNAS|pmid=16434472|volume=103|issue=6|pmc=1413653|doi=10.1073/pnas.0510407103|bibcode = 2006PNAS..103.1699A |pages=1699–704|doi-access=free}}</ref><ref>{{cite journal |last=Valko|first=M. |author2=Morris, H. |author3=Cronin, M. T. D. |date=2005|title=Metals, Toxicity and Oxidative stress|journal=Current Medicinal Chemistry |issue=10 |volume=12 |doi=10.2174/0929867053764635 |pmid=15892631 |pages=1161–208 |url=http://webmail.stuba.sk/~marian.valko/PDF/CMC_2005.pdf|url-status=dead|archive-url=https://web.archive.org/web/20170808080110/http://webmail.stuba.sk/~marian.valko/PDF/CMC_2005.pdf |archive-date=August 8, 2017}}</ref>