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===Adulthood=== In adulthood, the effects of aggression and violence against various groups of transgender people has also been documented in domains such as mental and physical health, and safety and discrimination in the military. Transgender related bias, or discrimination, victimization, and rejection, affects transgender adults and the severity of PTSD symptoms they report. A systematic review completed in 2018 examined 77 studies that reported mental health [[Disparities in mental health care|disparities]] and [[social stress]] felt by TGD adults. The analysis found associations between TGD identity and anxiety, depression, PTSD, substance use, and [[suicidality]], as well as added social stress factors such as violence, discrimination, and exclusion.<ref>{{Cite journal|last1=Valentine|first1=Sarah E.|last2=Shipherd|first2=Jillian C.|date=2018|title=A systematic review of social stress and mental health among transgender and gender non-conforming people in the United States|journal=Clinical Psychology Review|volume=66|pages=24β38|doi=10.1016/j.cpr.2018.03.003|pmid=29627104|pmc=6663089|issn=0272-7358}}</ref> When examining posttraumatic stress disorder and substance use in transgender adult communities, records indicated that transgender adults who have PTSD are more likely to be diagnosed with a [[substance use disorder]] within their lifetime.<ref>{{Cite journal|last1=Keuroghlian|first1=Alex S.|last2=Reisner|first2=Sari L.|last3=White|first3=Jaclyn M.|last4=Weiss|first4=Roger D.|date=1 July 2015|title=Substance Use and Treatment of Substance Use Disorders in a Community Sample of Transgender Adults|journal=Drug and Alcohol Dependence|volume=152|pages=139β146|doi=10.1016/j.drugalcdep.2015.04.008|issn=0376-8716|pmc=4458188|pmid=25953644}}</ref> A [[National Institutes of Health|National Institute of Health]] (NIH) analysis conducted with data collected at a [[Community health centers in the United States|community health center]] in the United States compared transgender and cisgender adult [[patient]]s on various possible health disparities. Their research showed that within their lifetime, transgender patients experienced more violence, childhood abuse, discrimination, and suicidal thoughts or suicide attempts when compared to their cisgender counterparts who had a similar age, education, ethnicity/race, and income.<ref>{{Cite journal|last1=Reisner|first1=Sari L.|last2=White|first2=Jaclyn M.|last3=Bradford|first3=Judith B.|last4=Mimiaga|first4=Matthew J.|date=2014|title=Transgender Health Disparities: Comparing Full Cohort and Nested Matched-Pair Study Designs in a Community Health Center|journal=LGBT Health|volume=1|issue=3|pages=177β184|doi=10.1089/lgbt.2014.0009|pmid=25379511|pmc=4219512|issn=2325-8292}}</ref>
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