Editing Solvent (section)

===Acute exposure===
Many solvents{{which?|date=November 2023}} can lead to a sudden loss of consciousness if [[inhalation|inhaled]] in large amounts.{{cn|date=November 2023}} Solvents like [[diethyl ether]] and [[chloroform]] have been used in medicine as [[anesthetics]], [[sedatives]], and [[hypnotics]] for a long time.{{when?|date=March 2024}} Many solvents (e.g. from [[gasoline]] or solvent-based glues) are abused recreationally in [[Volatile substance abuse|glue sniffing]], often with harmful long-term health effects such as [[neurotoxicity]] or [[cancer]].  Fraudulent substitution of [[1,5-pentanediol]] by the psychoactive [[1,4-butanediol]] by a subcontractor caused the [[Bindeez]] product recall.<ref>{{Cite web|url=https://www.theage.com.au/news/national/recall-for-toy-that-turns-into-drug/2007/11/06/1194329225773.html|title=National: Recall ordered for toy that turns into drug|website=www.theage.com.au|language=en|last = Rood|first = David|date=7 November 2007}}</ref>

[[Ethanol]] (grain alcohol) is a widely used and abused [[psychoactive drug]]. If ingested, the so-called "toxic alcohols" (other than ethanol) such as [[methanol]], [[1-propanol]], and [[ethylene glycol]] metabolize into toxic aldehydes and acids, which cause potentially fatal [[metabolic acidosis]].<ref name="Kraut_2018">{{cite journal | vauthors = Kraut JA, Mullins ME | title = Toxic Alcohols | journal = The New England Journal of Medicine | volume = 378 | issue = 3 | pages = 270–280 | date = January 2018 | pmid = 29342392 | doi = 10.1056/NEJMra1615295 | s2cid = 36652482 }}</ref> The commonly available alcohol solvent methanol can cause permanent blindness or death if ingested. The solvent [[2-Butoxyethanol|2-butoxyethanol]], used in [[fracking fluid]]s, can cause [[hypotension]] and metabolic acidosis.<ref>{{cite journal | vauthors = Hung T, Dewitt CR, Martz W, Schreiber W, Holmes DT | title = Fomepizole fails to prevent progression of acidosis in 2-butoxyethanol and ethanol coingestion | journal = Clinical Toxicology | volume = 48 | issue = 6 | pages = 569–71 | date = July 2010 | pmid = 20560787 | doi = 10.3109/15563650.2010.492350 | s2cid = 23257894 }}</ref>