Editing Phenytoin (section)

==Research==
Tentative evidence suggests that topical phenytoin is useful in wound healing in people with chronic skin wounds.<ref>{{cite journal | vauthors = Shaw J, Hughes CM, Lagan KM, Bell PM | title = The clinical effect of topical phenytoin on wound healing: a systematic review | journal = The British Journal of Dermatology | volume = 157 | issue = 5 | pages = 997–1004 | date = November 2007 | pmid = 17854378 | doi = 10.1111/j.1365-2133.2007.08160.x | s2cid = 23862219 }}</ref><ref>{{cite journal | vauthors = Bhatia A, Prakash S | title = Topical phenytoin for wound healing | journal = Dermatology Online Journal | volume = 10 | issue = 1 | pages = 5 | date = July 2004 | pmid = 15347487 | doi = 10.5070/D30Z3612W1 }}</ref> A meta-analysis also supported the use of phenytoin in managing various ulcers.<ref>{{cite journal| vauthors = Thangaraju P, Tamilselvan T, Venkatesan S, Eswaran T, Singh H, Giri VC, Ali MS |title=Topical Phenytoin for Managing Various Ulcers:A meta-analysis |journal= Sudan Medical Monitor |date= July 2015 |volume=10|issue=2|pages=63–67 |doi=10.4103/1858-5000.160951|s2cid=74076946 |doi-access=free }}</ref> Phenytoin is incorporated into compounded medications to optimize wound treatment, often in combination with [[misoprostol]].<ref>{{cite journal | vauthors = Riepl M | title = A Compendium of Compounding Agents and Formulations, Part 6: Additional Preparations for Refractory Dermal-wound Healing | journal = International Journal of Pharmaceutical Compounding | volume = 26 | issue = 6 | pages = 480–488 | date = 2022 | pmid = 36445767 | url = https://pubmed.ncbi.nlm.nih.gov/36445767/ }}</ref><ref>{{Cite journal | vauthors = Banov D, Song G, Foraida Z, Tkachova O, Zdoryk O, Carvalho M |title=Integrated In Vivo and In Vitro Evaluation of a Powder-to-Hydrogel, Film-Forming Polymer Complex Base with Tissue-Protective and Microbiome-Supportive Properties |journal=Gels |date=2024 |language=en |volume=10 |issue=7 |pages=447 |doi=10.3390/gels10070447 |doi-access=free |pmid=39057470 |pmc=11276563 |issn=2310-2861}}</ref>

Some clinical trials have explored whether phenytoin can be used as [[Neuroprotection|neuroprotector]] in [[multiple sclerosis]].<ref name="Raftopoulos_2016">{{cite journal | vauthors = Raftopoulos R, Hickman SJ, Toosy A, Sharrack B, Mallik S, Paling D, Altmann DR, Yiannakas MC, Malladi P, Sheridan R, Sarrigiannis PG, Hoggard N, Koltzenburg M, Gandini Wheeler-Kingshott CA, Schmierer K, Giovannoni G, Miller DH, Kapoor R | title = Phenytoin for neuroprotection in patients with acute optic neuritis: a randomised, placebo-controlled, phase 2 trial | journal = The Lancet. Neurology | volume = 15 | issue = 3 | pages = 259–269 | date = March 2016 | pmid = 26822749 | doi = 10.1016/S1474-4422(16)00004-1 | s2cid = 38835886 | doi-access = free }}</ref>