Editing Microtubule (section)

===Development===
The cytoskeleton formed by microtubules is essential to the [[morphogenesis|morphogenetic process]] of an organism's [[Developmental biology|development]]. For example, a network of polarized microtubules is required within the [[oocyte]] of ''[[Drosophila melanogaster]]'' during its [[Drosophila embryogenesis|embryogenesis]] in order to establish the axis of the egg. Signals sent between the follicular cells and the oocyte (such as factors similar to [[epidermal growth factor]]) cause the reorganization of the microtubules so that their (-) ends are located in the lower part of the oocyte, polarizing the structure and leading to the appearance of an anterior-posterior axis.<ref name="Van1999">{{Cite journal |vauthors=van Eeden F, St Johnston D |date=August 1999 |title=The polarisation of the anterior-posterior and dorsal-ventral axes during Drosophila oogenesis |journal=Current Opinion in Genetics & Development |volume=9 |issue=4 |pages=396–404 |doi=10.1016/S0959-437X(99)80060-4 |pmid=10449356}}</ref> This involvement in the body's architecture is also seen in [[mammal]]s.<ref name="Beddington1999">{{Cite journal |vauthors=Beddington RS, Robertson EJ |date=January 1999 |title=Axis development and early asymmetry in mammals |journal=Cell |volume=96 |issue=2 |pages=195–209 |doi=10.1016/S0092-8674(00)80560-7 |pmid=9988215 |s2cid=16264083 |doi-access=free}}</ref>

Another area where microtubules are essential is the [[development of the nervous system]] in higher [[vertebrate]]s, where tubulin's dynamics and those of the associated proteins (such as the microtubule-associated proteins) are finely controlled during the development of the [[nervous system]].<ref name="Tucker1990">{{Cite journal |vauthors=Tucker RP |year=1990 |title=The roles of microtubule-associated proteins in brain morphogenesis: a review |journal=Brain Research. Brain Research Reviews |volume=15 |issue=2 |pages=101–20 |doi=10.1016/0165-0173(90)90013-E |pmid=2282447 |s2cid=12641708}}</ref>