Editing Histone (section)

=== Chaperone Networks ===
The coordinated action of multiple histone chaperones forms an intricate network responsible for histone transport, [[Chromatin assembly factor 1]], and [[genome]] maintenance. Chaperone networks facilitate the transport of histones which are synthesized in the [[cytoplasm]] and must be escorted to the [[cell nucleus]]. This network ensures histones are deposited at the appropriate genomic locations, maintaining [[chromatin]] integrity and function.<ref>{{cite journal | vauthors = Li Z, Zhang Z | title = Histone chaperones: A multinodal highway network inside the cell | journal = Molecular Cell | volume = 83 | issue = 7 | pages = 1024–1026 | date = April 2023 | pmid = 37028413 | pmc = 10332477 | doi = 10.1016/j.molcel.2023.03.004 }}</ref>

Histone chaperones play a crucial role in responding to DNA damage by regulating chromatin accessibility. For example, in response to [[double strand breaks]], chaperones such as FACT and ASF1 help disassemble nucleosomes at damage sites, allowing repair factors to access the lesion. Once repair is completed, these chaperones facilitate the reassembly of [[Nucleosome|nucleosomes]], restoring chromatin structure and ensuring epigenetic information is maintained.<ref>{{cite journal | vauthors = Polo SE | title = Reshaping chromatin after DNA damage: the choreography of histone proteins | journal = Journal of Molecular Biology | volume = 427 | issue = 3 | pages = 626–636 | date = February 2015 | pmid = 24887097 | pmc = 5111727 | doi = 10.1016/j.jmb.2014.05.025 }}</ref> 

In addition to their role in genome stability, histone chaperones contribute to [[epigenetic inheritance]]. During cell division, chromatin states must be faithfully propagated to daughter cells. Chaperones help distribute parental histones onto newly synthesized DNA strands, preserving histone modifications and ensuring continuity of cellular identity. Disruptions in these processes can lead to epigenetic abnormalities associated with developmental disorders.<ref>{{cite journal | vauthors = Li Z, Zhang Z | title = Histone chaperones: A multinodal highway network inside the cell | journal = Molecular Cell | volume = 83 | issue = 7 | pages = 1024–1026 | date = April 2023 | pmid = 37028413 | pmc = 10332477 | doi = 10.1016/j.molcel.2023.03.004 }}</ref>