Editing Ehlers–Danlos syndrome (section)

==== Structural problems ====
Structurally, changes within the musculature in the intestine such as increased elastin, can lead to increased frequency of herniation.<ref name="Fikree_2017" /> Laxity of the phreno-esophageal and gastro-hepatic ligaments can lead to [[hiatal hernia]],<ref>{{cite journal | vauthors = Nelson AD, Mouchli MA, Valentin N, Deyle D, Pichurin P, Acosta A, Camilleri M | title = Ehlers Danlos syndrome and gastrointestinal manifestations: a 20-year experience at Mayo Clinic | journal = Neurogastroenterology and Motility | volume = 27 | issue = 11 | pages = 1657–1666 | date = November 2015 | pmid = 26376608 | doi = 10.1111/nmo.12665 | s2cid = 41431319}}</ref><ref name=pat>{{cite journal | vauthors = Thwaites PA, Gibson PR, Burgell RE | title = Hypermobile Ehlers–Danlos syndrome and disorders of the gastrointestinal tract: What the gastroenterologist needs to know | journal = Journal of Gastroenterology and Hepatology | volume = 37 | issue = 9 | pages = 1693–1709 | date = September 2022 | pmid = 35750466 | pmc = 9544979 | doi = 10.1111/jgh.15927}}</ref> which in turn can lead to commonly reported symptoms such as [[Gastroesophageal reflux disease|acid reflux]], abdominal pain, early [[satiety]], and bloating. Internal organ prolapses and intestinal [[Intussusception (medical disorder)|intussusceptions]] occur with greater frequency in patients with weakened connective tissues.<ref>{{cite journal | vauthors = Castori M, Morlino S, Pascolini G, Blundo C, Grammatico P | title = Gastrointestinal and nutritional issues in joint hypermobility syndrome/Ehlers–Danlos syndrome, hypermobility type | journal = American Journal of Medical Genetics. Part C, Seminars in Medical Genetics | volume = 169C | issue = 1 | pages = 54–75 | date = March 2015 | pmid = 25821092 | doi = 10.1002/ajmg.c.31431 | s2cid = 11773627}}</ref>