Editing Vancomycin (section)

===Intrinsic resistance===
A few Gram-positive bacteria, such as ''[[Leuconostoc]]'' and ''[[Pediococcus]]'', are intrinsically resistant to vancomycin, but they rarely cause disease in humans.<ref name="Swenson1990">{{cite journal | vauthors = Swenson JM, Facklam RR, Thornsberry C | title = Antimicrobial susceptibility of vancomycin-resistant Leuconostoc, Pediococcus, and Lactobacillus species | journal = Antimicrobial Agents and Chemotherapy | volume = 34 | issue = 4 | pages = 543–9 | date = April 1990 | pmid = 2344161 | pmc = 171641 | doi = 10.1128/AAC.34.4.543 }}</ref> Most ''[[Lactobacillus]]'' species are also intrinsically resistant to vancomycin,<ref name="Swenson1990"/> except for ''[[Lactobacillus acidophilus|L. acidophilus]]'' and ''[[Lactobacillus delbrueckii|L. delbrueckii]]'', which are sensitive.<ref name="pmid9569701">{{cite journal | vauthors = Hamilton-Miller JM, Shah S | title = Vancomycin susceptibility as an aid to the identification of lactobacilli | journal = Letters in Applied Microbiology | volume = 26 | issue = 2 | pages = 153–4 | date = February 1998 | pmid = 9569701 | doi = 10.1046/j.1472-765X.1998.00297.x | s2cid = 221924592 | doi-access = free }}</ref> Other Gram-positive bacteria with intrinsic resistance to vancomycin include ''[[Erysipelothrix rhusiopathiae]]'', ''[[Weissella|Weissella confusa]]'', and ''[[Clostridium innocuum]]''.<ref name="pmid18159347">{{cite journal | vauthors = Romney M, Cheung S, Montessori V | title = Erysipelothrix rhusiopathiae endocarditis and presumed osteomyelitis | journal = The Canadian Journal of Infectious Diseases | volume = 12 | issue = 4 | pages = 254–6 | date = July 2001 | pmid = 18159347 | pmc = 2094827 | doi = 10.1155/2001/912086 | doi-access = free }}</ref><ref name="pmid15150227">{{cite journal | vauthors = David V, Bozdogan B, Mainardi JL, Legrand R, Gutmann L, Leclercq R | title = Mechanism of intrinsic resistance to vancomycin in Clostridium innocuum NCIB 10674 | journal = Journal of Bacteriology | volume = 186 | issue = 11 | pages = 3415–22 | date = June 2004 | pmid = 15150227 | pmc = 415764 | doi = 10.1128/JB.186.11.3415-3422.2004 }}</ref><ref name="pmid21596906">{{cite journal | vauthors = Kumar A, Augustine D, Sudhindran S, Kurian AM, Dinesh KR, Karim S, Philip R | title = Weissella confusa: a rare cause of vancomycin-resistant Gram-positive bacteraemia | journal = Journal of Medical Microbiology | volume = 60 | issue = Pt 10 | pages = 1539–1541 | date = October 2011 | pmid = 21596906 | doi = 10.1099/jmm.0.027169-0 | doi-access = free }}</ref>

Most Gram-negative bacteria are intrinsically resistant to vancomycin because their outer membranes are impermeable to large glycopeptide molecules<ref name="Quintiliani Jr-1995">{{cite book | vauthors = Quintiliani Jr R, Courvalin P | chapter=Mechanisms of Resistance to Antimicrobial Agents | title=Manual of Clinical Microbiology | veditors=Murray PR, Baron EJ, Pfaller MA, Tenover FC, Yolken RH | publisher=ASM Press | location=Washington DC | year=1995 | edition=6th | pages=[https://archive.org/details/manualofclinical0000murr/page/1319 1319] | isbn=978-1-55581-086-3 | chapter-url-access=registration | chapter-url=https://archive.org/details/manualofclinical0000murr | url=https://archive.org/details/manualofclinical0000murr/page/1319 }}</ref> (with the exception of some non-[[Neisseria gonorrhoeae|gonococcal]] ''[[Neisseria]]'' species).<ref name="pmid7342289">{{cite journal | vauthors = Geraci JE, Wilson WR | title = Vancomycin therapy for infective endocarditis | journal = Reviews of Infectious Diseases | volume = 3 | issue = suppl | pages = S250-8 | year = 1981 | pmid = 7342289 | doi = 10.1093/clinids/3.Supplement_2.S250 }}</ref>