Editing Reelin (section)

===Psychotropic medication===
As reelin is being implicated in a number of brain disorders and its expression is usually measured posthumously, assessing the possible medication effects is important.<ref>{{cite journal | vauthors = Ishii K, Kubo KI, Nakajima K | title = Reelin and Neuropsychiatric Disorders | journal = Frontiers in Cellular Neuroscience | volume = 10 | pages = 229 | date = 2016-10-18 | pmid = 27803648 | pmc = 5067484 | doi = 10.3389/fncel.2016.00229 | doi-access = free }}</ref>

According to the epigenetic hypothesis, drugs that shift the balance in favour of [[demethylation]] have a potential to alleviate the proposed methylation-caused downregulation of RELN and GAD67. In one study, clozapine and sulpiride but not haloperidol and olanzapine were shown to increase the demethylation of both genes in mice pretreated with l-methionine.<ref name="pmid18757738" /> [[Valproic acid]], a [[histone deacetylase inhibitor]], when taken in combination with antipsychotics, is proposed to have some benefits. But there are studies conflicting the main premise of the epigenetic hypothesis, and a study by Fatemi et al. shows no increase in RELN expression by valproic acid; that indicates the need for further investigation.{{citation needed|date=January 2016}}

Fatemi et al. conducted the study in which RELN mRNA and reelin protein levels were measured in rat prefrontal cortex following a 21-day of [[intraperitoneal injection]]s of the following drugs:<ref name="Reelin_book_2008" />

{| class="wikitable" style="text-align:center"
|-
! style="width:125px;"| Reelin expression
! style="width:85px;"| [[Clozapine]]
! style="width:85px;"| [[Fluoxetine]]
! style="width:85px;"| [[Haloperidol]]
! style="width:85px;"| [[Lithium (medication)|Lithium]]
! style="width:85px;"| [[Olanzapine]]
! style="width:85px;"| [[Valproic Acid]]
|-
| protein || '''↓''' || '''↔''' || '''↓''' || '''↓''' || '''↑''' || '''↔'''
|-
| mRNA || '''↑''' || '''↑''' || '''↓''' || '''↑''' || '''↑''' || '''↓'''
|}
In 2009, Fatemi et al. published the more detailed work on rats using the same medication. Here, cortical expression of several participants ([[VLDLR]], [[DAB1]], [[GSK3B]]) of the signaling chain was measured besides reelin itself, and also the expression of [[GAD65]] and [[GAD67]].<ref name="pmid19359144" />