Editing Proteomics (section)

===New drug discovery===
One major development to come from the study of human genes and proteins has been the identification of potential new drugs for the treatment of disease. This relies on [[genome]] and [[proteome]] information to identify proteins associated with a disease, which computer software can then use as targets for new drugs. For example, if a certain protein is implicated in a disease, its 3D structure provides the information to design drugs to interfere with the action of the protein. A molecule that fits the active site of an enzyme, but cannot be released by the enzyme, inactivates the enzyme. This is the basis of new drug-discovery tools, which aim to find new drugs to inactivate proteins involved in disease. As genetic differences among individuals are found, researchers expect to use these techniques to develop personalized drugs that are more effective for the individual.<ref name="Vaidyanathan12">{{cite journal | vauthors = Vaidyanathan G | title = Redefining clinical trials: the age of personalized medicine | journal = Cell | volume = 148 | issue = 6 | pages = 1079–1080 | date = March 2012 | pmid = 22424218 | doi = 10.1016/j.cell.2012.02.041 | doi-access = free }}</ref>

Proteomics is also used to reveal complex plant-insect interactions that help identify candidate genes involved in the defensive response of plants to herbivory.<ref>{{cite journal | vauthors = Rakwal R, Komatsu S | title = Role of jasmonate in the rice (Oryza sativa L.) self-defense mechanism using proteome analysis | journal = Electrophoresis | volume = 21 | issue = 12 | pages = 2492–2500 | date = July 2000 | pmid = 10939463 | doi = 10.1002/1522-2683(20000701)21:12<2492::AID-ELPS2492>3.0.CO;2-2 | s2cid = 24979515 }}</ref><ref>{{cite journal | vauthors = Wu J, Baldwin IT | title = New insights into plant responses to the attack from insect herbivores | journal = Annual Review of Genetics | volume = 44 | pages = 1–24 | year = 2010 | pmid = 20649414 | doi = 10.1146/annurev-genet-102209-163500 }}</ref><ref>{{cite journal | vauthors = Sangha JS, Chen YH, Kaur J, Khan W, Abduljaleel Z, Alanazi MS, Mills A, Adalla CB, Bennett J, Prithiviraj B, Jahn GC, Leung H | display-authors = 6 | title = Proteome Analysis of Rice (Oryza sativa L.) Mutants Reveals Differentially Induced Proteins during Brown Planthopper (Nilaparvata lugens) Infestation | journal = International Journal of Molecular Sciences | volume = 14 | issue = 2 | pages = 3921–3945 | date = February 2013 | pmid = 23434671 | pmc = 3588078 | doi = 10.3390/ijms14023921 | doi-access = free }}</ref>

A branch of proteomics called [[chemoproteomics]] provides numerous tools and techniques to detect protein targets of drugs.<ref>{{cite journal | vauthors = Moellering RE, Cravatt BF | title = How chemoproteomics can enable drug discovery and development | journal = Chemistry & Biology | volume = 19 | issue = 1 | pages = 11–22 | date = January 2012 | pmid = 22284350 | pmc = 3312051 | doi = 10.1016/j.chembiol.2012.01.001 }}</ref>