Editing Mitochondrion (section)

====Perspective====
The MAM is a critical signaling, metabolic, and trafficking hub in the cell that allows for the integration of ER and mitochondrial physiology. Coupling between these organelles is not simply structural but functional as well and critical for overall cellular physiology and [[homeostasis]]. The MAM thus offers a perspective on mitochondria that diverges from the traditional view of this organelle as a static, isolated unit appropriated for its metabolic capacity by the cell.<ref name="Csordás-2018">{{cite journal | vauthors = Csordás G, Weaver D, Hajnóczky G | title = Endoplasmic Reticulum-Mitochondrial Contactology: Structure and Signaling Functions | journal = Trends in Cell Biology | volume = 28 | issue = 7 | pages = 523–540 | date = July 2018 | pmid = 29588129 | pmc = 6005738 | doi = 10.1016/j.tcb.2018.02.009 }}</ref> Instead, this mitochondrial-ER interface emphasizes the integration of the mitochondria, the product of an endosymbiotic event, into diverse cellular processes. Recently it has also been shown, that mitochondria and MAM-s in neurons are anchored to specialised intercellular communication sites (so called somatic-junctions). [[Microglia]]l processes monitor and protect neuronal functions at these sites, and MAM-s are supposed to have an important role in this type of cellular quality-control.<ref name="Cserép-2020">{{cite journal | vauthors = Cserép C, Pósfai B, Lénárt N, Fekete R, László ZI, Lele Z, Orsolits B, Molnár G, Heindl S, Schwarcz AD, Ujvári K, Környei Z, Tóth K, Szabadits E, Sperlágh B, Baranyi M, Csiba L, Hortobágyi T, Maglóczky Z, Martinecz B, Szabó G, Erdélyi F, Szipőcs R, Tamkun MM, Gesierich B, Duering M, Katona I, Liesz A, Tamás G, Dénes Á | title = Microglia monitor and protect neuronal function through specialized somatic purinergic junctions | journal = Science | volume = 367 | issue = 6477 | pages = 528–537 | date = January 2020 | pmid = 31831638 | doi = 10.1126/science.aax6752 | bibcode = 2020Sci...367..528C | url = https://epub.ub.uni-muenchen.de/76442/1/Cserep_Posfai_et_al_accepted.pdf }}</ref>