Editing Fructose (section)

=== Synthesis of triglyceride from DHAP and glyceraldehyde 3-phosphate ===
Carbons from dietary fructose are found in both the [[free fatty acid]] and glycerol [[Moiety (chemistry)|moieties]] of plasma triglycerides. High fructose consumption can lead to excess [[pyruvate]] production, causing a buildup of [[Krebs cycle]] intermediates.<ref name=McGrane>{{cite book | first=MM | last=McGrane | title=Carbohydrate metabolism: Synthesis and oxidation | place=Missouri | publisher=Saunders, Elsevier | year=2006 | isbn=978-1-4160-0209-3 | pages=258–277}}</ref> Accumulated citrate can be transported from the [[mitochondrion|mitochondria]] into the [[cytosol]] of [[hepatocytes]], converted to [[acetyl CoA]] by citrate lyase and directed toward fatty acid synthesis.<ref name=McGrane /><ref name=Sul>{{cite book | first=HS | last=Sul | title=Metabolism of Fatty Acids, Acylglycerols, and Sphingolipids | place=Missouri | publisher=Saunders, Elsevier | year=2006 | isbn=978-1-4160-0209-3 | pages=450–467}}</ref> In addition, DHAP can be converted to glycerol 3-phosphate, providing the glycerol backbone for the triglyceride molecule.<ref name=Sul /> Triglycerides are incorporated into [[very-low-density lipoprotein]]s (VLDL), which are released from the liver destined toward peripheral tissues for storage in both fat and muscle cells.

[[File:Fructose-triglyceride.svg|thumb|center|400px|Metabolic conversion of fructose to triglyceride in the liver]]