Editing Ehlers–Danlos syndrome (section)

==== Functional problems ====
Functionally, small bowel dysmotility, [[Gastroparesis|delayed gastric emptying]] and delayed colonic transit are commonly related to EDS.<ref>{{cite journal | vauthors = Zarate N, Farmer AD, Grahame R, Mohammed SD, Knowles CH, Scott SM, Aziz Q | title = Unexplained gastrointestinal symptoms and joint hypermobility: is connective tissue the missing link? | journal = Neurogastroenterology and Motility | volume = 22 | issue = 3 | pages = 252–e78 | date = March 2010 | pmid = 19840271 | doi = 10.1111/j.1365-2982.2009.01421.x | s2cid = 11516253}}</ref><ref>{{cite journal | vauthors = Menys A, Keszthelyi D, Fitzke H, Fikree A, Atkinson D, Aziz Q, Taylor SA | title = A magnetic resonance imaging study of gastric motor function in patients with dyspepsia associated with Ehlers–Danlos Syndrome-Hypermobility Type: A feasibility study | journal = Neurogastroenterology and Motility | volume = 29 | issue = 9 | date = September 2017 | pmid = 28568908 | doi = 10.1111/nmo.13090 | s2cid = 776971 | url = https://cris.maastrichtuniversity.nl/en/publications/e950bcd8-6e97-46d7-9f88-9681b5125293}}</ref> These changes in transit speeds within the gastrointestinal system can cause a host of symptoms, including but not limited to abdominal pain, [[bloating]], [[nausea]], reflux symptoms, [[vomiting]], [[constipation]], and [[diarrhea]].<ref>{{cite journal | vauthors = Zeitoun JD, Lefèvre JH, de Parades V, Séjourné C, Sobhani I, Coffin B, Hamonet C | title = Functional digestive symptoms and quality of life in patients with Ehlers–Danlos syndromes: results of a national cohort study on 134 patients | journal = PLOS ONE | volume = 8 | issue = 11 | pages = e80321 | date = 2013-11-22 | pmid = 24278273 | pmc = 3838387 | doi = 10.1371/journal.pone.0080321 | bibcode = 2013PLoSO...880321Z | doi-access = free | veditors = Karhausen J}}</ref>

Some studies also suggest problems with the [[liver]], which is in large part responsible for [[bilirubin]] conjugation. Although research in this area is sparse, patients with joint hypermobility were found to have higher rates of indirect [[hyperbilirubinemia]] than control groups.<ref>{{cite journal | vauthors = Çınar M, Çakar M, Öztürk K, Çetindağlı İ, Yılmaz S, Dinç A | title = Investigation of joint hypermobility in individuals with hyperbilirubinemia | journal = European Journal of Rheumatology | volume = 4 | issue = 1 | pages = 36–39 | date = March 2017 | pmid = 28293451 | pmc = 5335885 | doi = 10.5152/eurjrheum.2016.16051}}</ref>