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===Medication=== Many different medications have been used to treat bruxism,<ref name="Macedo 2009" /> including [[benzodiazepine]]s,<!--<ref name="Macedo 2009" /> --> [[anticonvulsant]]s,<!--<ref name="Macedo 2009" /> --> [[beta blocker]]s,<!--<ref name="Macedo 2009" /> --> [[dopamine]] agents,<!--<ref name="Macedo 2009" /> --> [[antidepressant]]s,<!--<ref name="Macedo 2009" /> --> [[muscle relaxant]]s,<!--<ref name="Macedo 2009" /> --> and others. However, there is little, if any, evidence for their respective and comparative efficacies with each other and when compared to a [[placebo]].{{citation needed|reason=several studies can be cited; this is contradicted in next paragraph re: 'promising initial results' | date=December 2013}} A multiyear [[systematic review]] to investigate the evidence for drug treatments in sleep bruxism published in 2014 (''Pharmacotherapy for Sleep Bruxism''. Macedo, et al.) found "insufficient evidence on the effectiveness of pharmacotherapy for the treatment of sleep bruxism."<ref>Macedo CR, Macedo EC, Torloni MR, Silva AB, Prado GF. Pharmacotherapy for sleep bruxism. Cochrane Database of Systematic Reviews 2014, Issue 10. Art. No.: CD005578. DOI: 10.1002/14651858.CD005578.pub2.</ref> Specific drugs that have been studied in sleep bruxism are [[clonazepam]],<ref name=Machado2011>{{cite journal|last1=Machado|first1=Eduardo|last2=Machado|first2=Patricia|last3=Cunali|first3=Paulo Afonso|last4=Dal Fabbro|first4=Cibele|title=Sleep bruxism: Therapeutic possibilities based in evidences|journal=Dental Press Journal of Orthodontics|volume=16|issue=2|year=2011|pages=58β64|doi=10.1590/S2176-94512011000200008|doi-access=free}}</ref> [[levodopa]],<ref name=Machado2011/> [[amitriptyline]],<ref name=Machado2011/> [[bromocriptine]],<ref name=Machado2011/> [[pergolide]],<!--<ref name="Macedo 2009" /> --> [[clonidine]],<!--<ref name="Macedo 2009" /> --> [[propranolol]],<!--<ref name="Macedo 2009" /> --> and [[l-tryptophan]],<!--<ref name="Macedo 2009" /> --> with some showing no effect and others appear to have promising initial results; however, it has been suggested that further safety testing is required before any evidence-based clinical recommendations can be made.<ref name="Macedo 2009" /> When bruxism is related to the use of selective [[serotonin]] reuptake inhibitors in depression, adding [[buspirone]] has been reported to resolve the side effect.<ref name="Glick 2003" /> Tricyclic antidepressants have also been suggested to be preferable to selective serotonin reuptake inhibitors in people with bruxism, and may help with the pain.<ref name="Buescher 2007">{{cite journal |author=Buescher JJ |title=Temporomandibular joint disorders |journal=American Family Physician |volume=76 |issue=10 |pages=1477β82 |date=November 2007 |pmid=18052012 |url=http://www.aafp.org/link_out?pmid=18052012}}</ref>
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