Editing Antidepressant (section)

===Emotional blunting===
Certain antidepressants may cause [[emotional blunting]], characterized by a reduced intensity of both positive and negative emotions as well as symptoms of [[apathy]], [[psychological indifference|indifference]], and [[amotivational syndrome|amotivation]].<ref name="pmid34908941">{{cite journal|vauthors=Marazziti D, Mucci F, Tripodi B, Carbone MG, Muscarella A, Falaschi V, Baroni S|title=Emotional Blunting, Cognitive Impairment, Bone Fractures, and Bleeding as Possible Side Effects of Long-Term Use of SSRIs|journal=Clin Neuropsychiatry|volume=16|issue=2|pages=75–85|date=April 2019|pmid=34908941|pmc=8650205}}</ref><ref name="pmid34970173">{{cite journal|vauthors=Ma H, Cai M, Wang H|title=Emotional Blunting in Patients With Major Depressive Disorder: A Brief Non-systematic Review of Current Research|journal=Front Psychiatry|volume=12|pages=792960|date=2021|pmid=34970173|pmc=8712545|doi=10.3389/fpsyt.2021.792960|doi-access=free}}</ref><ref name="pmid15330228">{{cite journal|vauthors=Barnhart WJ, Makela EH, Latocha MJ|title=SSRI-induced apathy syndrome: a clinical review|journal=J Psychiatr Pract|volume=10|issue=3|pages=196–9|date=May 2004|pmid=15330228|doi=10.1097/00131746-200405000-00010|s2cid=26935586}}</ref><ref name="pmid21103140">{{cite journal|vauthors=Sansone RA, Sansone LA|title=SSRI-Induced Indifference|journal=Psychiatry (Edgmont)|volume=7|issue=10|pages=14–8|date=October 2010|pmid=21103140|pmc=2989833}}</ref><ref name="pmid19721109">{{cite journal|vauthors=Price J, Cole V, Goodwin GM|title=Emotional side-effects of selective serotonin reuptake inhibitors: qualitative study|journal=Br J Psychiatry|volume=195|issue=3|pages=211–7|date=September 2009|pmid=19721109|doi=10.1192/bjp.bp.108.051110|doi-access=free}}</ref><ref name="pmid28628765">{{cite journal|vauthors=Goodwin GM, Price J, De Bodinat C, Laredo J|title=Emotional blunting with antidepressant treatments: A survey among depressed patients|journal=J Affect Disord|volume=221|pages=31–35|date=October 2017|pmid=28628765|doi=10.1016/j.jad.2017.05.048|s2cid=3755520|url=https://ora.ox.ac.uk/objects/uuid:8a7067a3-7b21-481f-ac80-32f1929d3ff7}}</ref><ref name="pmid29866014">{{cite journal|vauthors=Read J, Williams J|title=Adverse Effects of Antidepressants Reported by a Large International Cohort: Emotional Blunting, Suicidality, and Withdrawal Effects|journal=Curr Drug Saf|volume=13|issue=3|pages=176–186|date=2018|pmid=29866014|doi=10.2174/1574886313666180605095130|s2cid=46934452|url=http://roar.uel.ac.uk/7564/1/7564.pdf}}</ref><ref name="pmid35346413">{{cite journal|vauthors=Camino S, Strejilevich SA, Godoy A, Smith J, Szmulewicz A|title=Are all antidepressants the same? The consumer has a point|journal=Psychol Med|volume=53|issue=9|pages=4004–4011|date=March 2022|pmid=35346413|doi=10.1017/S0033291722000678|s2cid=247777403}}</ref><ref name="pmid11436958">{{cite journal|vauthors=Garland EJ, Baerg EA|title=Amotivational syndrome associated with selective serotonin reuptake inhibitors in children and adolescents|journal=J Child Adolesc Psychopharmacol|volume=11|issue=2|pages=181–6|date=2001|pmid=11436958|doi=10.1089/104454601750284090}}</ref> It may be experienced as either beneficial or detrimental depending on the situation.<ref name="pmid26407780">{{cite journal|vauthors=Moncrieff J|title=Antidepressants: misnamed and misrepresented|journal=World Psychiatry|volume=14|issue=3|pages=302–3|date=October 2015|pmid=26407780|pmc=4592647|doi=10.1002/wps.20243}}</ref> This side effect has been particularly associated with serotonergic antidepressants like SSRIs and SNRIs but may be less with atypical antidepressants like bupropion, [[agomelatine]], and [[vortioxetine]].<ref name="pmid34970173" /><ref name="pmid35346413" /><ref name="pmid23823799">{{cite journal|vauthors=Corruble E, de Bodinat C, Belaïdi C, Goodwin GM|title=Efficacy of Aomelatine and Escitalopram on depression, subjective sleep and emotional experiences in patients with major depressive disorder: a 24-wk randomized, controlled, double-blind trial|journal=Int J Neuropsychopharmacol|volume=16|issue=10|pages=2219–34|date=November 2013|pmid=23823799|doi=10.1017/S1461145713000679|doi-access=free}}</ref><ref name="pmid33516560">{{cite journal|vauthors=Fagiolini A, Florea I, Loft H, Christensen MC|title=Effectiveness of Vortioxetine on Emotional Blunting in Patients with Major Depressive Disorder with inadequate response to SSRI/SNRI treatment|journal=J Affect Disord|volume=283|pages=472–479|date=March 2021|pmid=33516560|doi=10.1016/j.jad.2020.11.106|s2cid=228877905|doi-access=free|hdl=11365/1137950|hdl-access=free}}</ref> Higher doses of antidepressants seem to be more likely to produce emotional blunting than lower doses.<ref name="pmid34970173" /> Emotional blunting can be decreased by reducing dosage, discontinuing the medication, or switching to a different antidepressant that may have less propensity for causing this side effect.<ref name="pmid34970173" />