Editing Valproate (section)

===Terminology===
Valproate is a negative ion. The [[conjugate base|conjugate acid]] of valproate is valproic acid (VPA). Valproic acid is fully ionized into valproate at the physiologic pH of the human body, and valproate is the active form of the drug. Sodium valproate is the sodium [[salt (chemistry)|salt]] of valproic acid. Divalproex sodium is a [[coordination complex]] composed of equal parts of valproic acid and sodium valproate.<ref>{{Cite book|url=https://www.medicinescomplete.com/mc/martindale/current/ms-10447-z.htm|title=Martindale: The Complete Drug Reference|publisher=Pharmaceutical Press|veditors=Brayfield A|location=London|access-date=3 March 2018|archive-date=27 August 2021|archive-url=https://web.archive.org/web/20210827175406/https://about.medicinescomplete.com/wp-content/themes/mc-marketing/assets/images/favicons-tiles/favicon.ico|url-status=live}}</ref>

====Brand names of valproic acid====
<!-- Please do not add sodium valproate-based products to this list. That drug has its own list below -->
Branded products include:
{{Div col|colwidth=30em}}
* Absenor ([[Orion Corporation (pharmaceutical company)|Orion Corporation]] Finland)
* Convulex ([[G.L. Pharma GmbH]] Austria)
* Depakene ([[Abbott Laboratories]] in US and Canada)<ref name="Depakene FDA label">{{cite web | title=Depakene- valproic acid capsule, liquid filled | website=DailyMed | date=19 September 2019 | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a0288919-75bf-4752-975f-40579572c0f7 | access-date=14 April 2020 | archive-date=11 July 2020 | archive-url=https://web.archive.org/web/20200711130306/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a0288919-75bf-4752-975f-40579572c0f7 | url-status=live }}</ref>
* Depakin ([[Sanofi|Sanofi S.R.L.]] Italy)<ref name="Depakin AIFA">{{Cite web |url=https://farmaci.agenziafarmaco.gov.it/bancadatifarmaci/farmaco?farmaco=022483 |title=Depakin - Banca Dati Farmaci dell'AIFA |date=6 June 2023 |access-date=6 June 2023 |website=farmaci.agenziafarmaco.gov.it |archive-url=https://web.archive.org/web/20230606001333/https://farmaci.agenziafarmaco.gov.it/bancadatifarmaci/farmaco?farmaco=022483 |archive-date=6 June 2023 |url-status=live |publisher=[[Italian Medicines Agency]] |language=it |trans-title=Depakin - The AIFA Medicines Database}}</ref>
* Depakine ([[Sanofi Aventis]] France)
* Depakine ([[Sanofi Synthelabo]] Romania)
* Depalept ([[Sanofi Aventis]] Israel)
* Deprakine ([[Sanofi Aventis]] Finland)
* Encorate ([[Sun Pharmaceuticals]] India)
* Epilim ([[Sanofi Synthelabo]] Australia and South Africa)
* Stavzor ([[Noven Pharmaceuticals|Noven Pharmaceuticals Inc.]])
* Valcote ([[Abbott Laboratories]] Argentina)
* Valpakine ([[Sanofi Aventis]] Brazil)
* Orfiril (Desitin Arzneimittel GmbH Norway)
{{div col end}}

====Brand names of sodium valproate====

=====Portugal=====
* Tablets{{snd}} Diplexil-R by [[Bial]].

=====United States=====
* Intravenous injection{{snd}} Depacon by Abbott Laboratories.
* Syrup{{snd}} Depakene by Abbott Laboratories. (Note: Depakene ''capsules'' are valproic acid).
* Depakote tablets are a mixture of sodium valproate and valproic acid.
* Tablets{{snd}} Eliaxim by Bial.

=====Australia=====
* Epilim Crushable Tablets Sanofi<ref name="Epilim TGA PI">{{cite web | title=Australian product information epilim (sodium valproate) crushable tablets, enteric-coated tablets, syrup, liquid | website=TGA eBS | date=15 April 2020 | url=http://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2010-PI-05620-3 | format=PDF | access-date=15 April 2020 | archive-date=15 March 2020 | archive-url=https://web.archive.org/web/20200315112531/https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2010-PI-05620-3 | url-status=live }}</ref>
* Epilim Sugar Free Liquid Sanofi<ref name="Epilim TGA PI" />
* Epilim Syrup Sanofi<ref name="Epilim TGA PI" />
* Epilim Tablets Sanofi<ref name="Epilim TGA PI" />
* Sodium Valproate Sandoz Tablets Sanofi
* Valpro Tablets Alphapharm
* Valproate Winthrop Tablets Sanofi
* Valprease tablets Sigma

=====New Zealand=====
* Epilim by Sanofi-Aventis

All the above formulations are [[Pharmaceutical Management Agency|Pharmac]]-subsidised.<ref>{{cite web |url= http://www.pharmac.govt.nz/Schedule?osq=Sodium%20valproate |title= Sodium valproate -- Pharmaceutical Schedule |publisher= Pharmaceutical Management Agency |access-date= 22 June 2014 |url-status= dead |archive-url= https://web.archive.org/web/20160304081454/http://www.pharmac.govt.nz/Schedule?osq=Sodium%20valproate |archive-date= 4 March 2016 }}</ref>

=====UK=====
* Depakote Tablets (as in USA)
* Tablets{{snd}} Orlept by Wockhardt and Epilim by Sanofi
* Oral solution{{snd}} Orlept Sugar Free by Wockhardt and Epilim by Sanofi
* Syrup{{snd}} Epilim by Sanofi-Aventis
* Intravenous injection{{snd}} Epilim Intravenous by Sanofi
* Extended release tablets{{snd}} Epilim Chrono by Sanofi is a combination of sodium valproate and valproic acid in a 2.3:1 ratio.
* Enteric-coated tablets{{snd}} Epilim EC200 by Sanofi is a 200&nbsp;mg sodium valproate [[Enteric coating|enteric-coated]] tablet.

======UK only======
* Capsules{{snd}} Episenta prolonged release by Beacon
* Sachets{{snd}} Episenta prolonged release by Beacon
* Intravenous solution for injection{{snd}} Episenta solution for injection by Beacon

=====Germany, Switzerland, Norway, Finland, Sweden=====
* Tablets{{snd}} Orfiril by Desitin Pharmaceuticals
* Intravenous injection{{snd}} Orfiril IV by Desitin Pharmaceuticals

=====South Africa=====
* Syrup{{snd}} Convulex by Byk Madaus<ref>{{Cite web |url=http://home.intekom.com/pharm/byk/convulex.html |title=South African Electronic Package Inserts: Convulex |access-date=2 January 2006 |archive-date=12 August 2010 |archive-url=https://web.archive.org/web/20100812052527/http://home.intekom.com/pharm/byk/convulex.html |url-status=dead }}</ref>
* Tablets{{snd}} Epilim by Sanofi-synthelabo

=====Malaysia=====
* Tablets{{snd}} Epilim (''200 ENTERIC COATED'') by Sanofi-Aventis
* Controlled release tablets{{snd}} Epilim Chrono (''500 CONTROLLED RELEASE'') by Sanofi-Aventis<ref name="Sanofi in Malaysia Products - Epilim & Epilim Chrono">{{cite web |title=Malaysian Package Inserts: Epilim |url=https://www.sanofi.com.my/en/products/epilim |access-date=5 June 2023 |archive-date=5 June 2023 |archive-url=https://web.archive.org/web/20230605142828/https://www.sanofi.com.my/en/products/epilim |url-status=live }}</ref>

=====Romania=====
* Companies are SANOFI-AVENTIS FRANCE, GEROT PHARMAZEUTIKA GMBH and DESITIN ARZNEIMITTEL GMBH
* Types are Syrup, Extended release mini tablets, Gastric resistant coated tablets, Gastric resistant soft capsules, Extended release capsules, Extended release tablets and Extended release coated tablets

=====Canada=====
* Intravenous injection{{snd}} Epival or Epiject by [[Abbott Laboratories]].
* Syrup{{snd}} Depakene by [[Abbott Laboratories]] its generic formulations include [https://web.archive.org/web/20070928082043/http://www.apotex.ca/Products/EN/Detail.asp?MaterialNumber=000000000000042290 Apo-Valproic] and [https://web.archive.org/web/20080115210712/http://www.ratiopharm.ca/e/Products/productSearch.asp?Cap=V ratio-Valproic].

=====Japan=====
* Tablets{{snd}} Depakene by [[Kyowa Hakko Kirin]]
* Extended release tablets{{snd}} Depakene-R by Kyowa Hakko Kogyo and Selenica-R by [[Kowa Co.|Kowa]]
* Syrup{{snd}} Depakene by Kyowa Hakko Kogyo

=====Europe=====
In much of Europe, Dépakine and Depakine Chrono (tablets) are equivalent to Epilim and Epilim Chrono above.

=====Taiwan=====
* Tablets (white round tablet){{snd}} Depakine ({{lang-zh|c=帝拔癲|p=di-ba-dian}}) by [[Sanofi-Aventis|Sanofi Winthrop Industrie]] (France)

=====Iran=====
* Tablets{{snd}} Epival 200 (enteric coated tablet) and Epival 500 (extended release tablet) by Iran Najo
* Slow release tablets{{snd}} Depakine Chrono by [[Sanofi-Aventis|Sanofi Winthrop Industrie]] (France)

=====Israel=====
Depalept and Depalept Chrono (extended release tablets) are equivalent to Epilim and Epilim Chrono above. Manufactured and distributed by [[Sanofi-Aventis]].

===== India, Russia and [[Commonwealth of Independent States|CIS]] countries =====
* Valparin Chrono by Sanofi India
* Valprol CR by Intas Pharmaceutical (India)
* Encorate Chrono by Sun Pharmaceutical (India)
* Serven Chrono by Leeven APL Biotech (India)

=====Uruguay=====
* Tablets{{snd}} DI DPA by Megalabs

====Brand names of valproate semisodium====
* Brazil{{snd}} Depakote by [[Abbott Laboratories]] and Torval CR by Torrent do Brasil
* Canada{{snd}} Epival by Abbott Laboratories
* Mexico{{snd}} Epival and Epival ER (extended release) by Abbott Laboratories
* United Kingdom{{snd}} Depakote (for psychiatric conditions) and Epilim (for epilepsy) by [[Sanofi-Aventis]] and generics
* United States{{snd}} Depakote and Depakote ER (extended release) by Abbott Laboratories and generics<ref name="Depakote FDA label" />
* India{{snd}} Valance and Valance OD by Abbott Healthcare Pvt Ltd, Divalid ER by Linux laboratories Pvt Ltd, Valex ER by Sigmund Promedica, Dicorate by Sun Pharma
* Germany{{snd}} Ergenyl Chrono by Sanofi-Aventis and generics
* Chile{{snd}} Valcote and Valcote ER by Abbott Laboratories
* France and other European countries{{snd}} Depakote
* Peru{{snd}} Divalprax by AC Farma Laboratories
* China{{snd}} Diprate OD