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===Complicated=== Complicated UTIs are more difficult to treat and usually requires more aggressive evaluation, treatment, and follow-up.<ref name="Bryan2002">{{cite book | vauthors = Bryan CS |title=Infectious diseases in primary care |publisher=W.B. Saunders |location=Philadelphia |year=2002 |pages=319 |isbn=978-0-7216-9056-8 |url=http://pathmicro.med.sc.edu/infectious%20disease/Urinary%20Tract%20Infections.htm |url-status=live |archive-url=https://web.archive.org/web/20120213052452/http://pathmicro.med.sc.edu/Infectious%20Disease/Urinary%20Tract%20Infections.htm |archive-date=13 February 2012 }}</ref> It may require identifying and addressing the underlying complication.<ref>{{cite journal | vauthors = Wagenlehner FM, Vahlensieck W, Bauer HW, Weidner W, Piechota HJ, Naber KG | title = Prevention of recurrent urinary tract infections | journal = Minerva Urologica e Nefrologica | volume = 65 | issue = 1 | pages = 9–20 | date = March 2013 | pmid = 23538307 }}</ref> Increasing antibiotic resistance is causing concern about the future of treating those with complicated and recurrent UTI.<ref name="Pallett-2010">{{cite journal | vauthors = Pallett A, Hand K | title = Complicated urinary tract infections: practical solutions for the treatment of multiresistant Gram-negative bacteria | journal = The Journal of Antimicrobial Chemotherapy | volume = 65 | issue = Suppl 3 | pages = iii25–iii33 | date = November 2010 | pmid = 20876625 | doi = 10.1093/jac/dkq298 | doi-access = free }}</ref><ref name="Shepherd-2013">{{cite journal | vauthors = Shepherd AK, Pottinger PS | title = Management of urinary tract infections in the era of increasing antimicrobial resistance | journal = The Medical Clinics of North America | volume = 97 | issue = 4 | pages = 737–57, xii | date = July 2013 | pmid = 23809723 | doi = 10.1016/j.mcna.2013.03.006 }}</ref><ref>{{cite journal | vauthors = Karlović K, Nikolić J, Arapović J | title = Ceftriaxone treatment of complicated urinary tract infections as a risk factor for enterococcal re-infection and prolonged hospitalization: A 6-year retrospective study | journal = Bosnian Journal of Basic Medical Sciences | volume = 18 | issue = 4 | pages = 361–366 | date = November 2018 | pmid = 29750894 | pmc = 6252101 | doi = 10.17305/bjbms.2018.3544 }}</ref>
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