Editing Tacrolimus (section)

===Ulcerative colitis===
Tacrolimus has been used to suppress the inflammation associated with [[ulcerative colitis]] (UC), a form of [[inflammatory bowel disease]]. Although almost exclusively used in trial cases only, tacrolimus has shown to be significantly effective in the suppression of flares of UC.<ref>{{cite journal | vauthors = Baumgart DC, Pintoffl JP, Sturm A, Wiedenmann B, Dignass AU | title = Tacrolimus is safe and effective in patients with severe steroid-refractory or steroid-dependent inflammatory bowel disease--a long-term follow-up | journal = The American Journal of Gastroenterology | volume = 101 | issue = 5 | pages = 1048–1056 | date = May 2006 | pmid = 16573777 | doi = 10.1111/j.1572-0241.2006.00524.x | s2cid = 10233231 }}</ref> A 2022 updated Cochrane systematic review found that tacrolimus may be superior to placebo in achieving remission and improvement in UC.<ref>{{cite journal | vauthors = Gordon M, Sinopoulou V, Akobeng AK, Pana M, Gasiea R, Moran GW | title = Tacrolimus (FK506) for induction of remission in corticosteroid-refractory ulcerative colitis | journal = The Cochrane Database of Systematic Reviews | volume = 2022 | issue = 4 | pages = CD007216 | date = April 2022 | pmid = 35388476 | pmc = 8987360 | doi = 10.1002/14651858.CD007216.pub2 }}</ref>