Editing Paroxetine (section)

== Other organisms ==
Paroxetine is a common finding in wastewater.<ref name="Runoff" /> It is highly toxic to the alga ''Pseudokirchneriella subcapitata'' (syn. ''[[Raphidocelis subcapitata]]'').<ref name="Runoff">
   {{Unbulleted list citebundle
      |{{*}} {{cite journal | vauthors = Chia MA, Lorenzi AS, Ameh I, Dauda S, Cordeiro-Araújo MK, Agee JT, Okpanachi IY, Adesalu AT | title = Susceptibility of phytoplankton to the increasing presence of active pharmaceutical ingredients (APIs) in the aquatic environment: A review | journal = [[Aquatic Toxicology]] | volume = 234 | pages = 105809 | date = May 2021 | pmid = 33780670 | doi = 10.1016/j.aquatox.2021.105809 | publisher = [[Elsevier]] | bibcode = 2021AqTox.23405809C | s2cid = 232419482 }}
      |{{*}} {{cite journal | vauthors = Christensen AM, Faaborg-Andersen S, Ingerslev F, Baun A | title = Mixture and single-substance toxicity of selective serotonin reuptake inhibitors toward algae and crustaceans | journal = [[Environmental Toxicology and Chemistry]] | volume = 26 | issue = 1 | pages = 85–91 | date = January 2007 | pmid = 17269464 | doi = 10.1897/06-219R.1 | publisher = [[John Wiley & Sons, Inc.]] | s2cid = 6562531 | doi-access = free | bibcode = 2007EnvTC..26...85C }}
   }}
</ref>

It also is toxic to the soil nematode ''[[Caenorhabditis elegans]]''.<ref name="Repurposing">
   {{Unbulleted list citebundle
      |{{*}} {{cite journal | vauthors = Mangoni AA, Tuccinardi T, Collina S, Vanden Eynde JJ, Muñoz-Torrero D, Karaman R, Siciliano C, de Sousa ME, Prokai-Tatrai K, Rautio J, Guillou C, Gütschow M, Galdiero S, Liu H, Agrofoglio LA, Sabatier JM, Hulme C, Kokotos G, You Q, Gomes PA | title = Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-3 | journal = [[Molecules (journal)|Molecules]] | volume = 23 | issue = 7 | page = 1596 | date = June 2018 | pmid = 29966350 | doi = 10.3390/molecules23071596 | publisher = [[MDPI AG]] | pmc = 6099979 | s2cid = 49644934 | doi-access = free }}<!-- Published by MDPI but highly cited including by Jimenez-Lopez et al., 2020, Elmaaty et al., 2021, and Sridhar et al., 2020. -->
      |{{*}} {{cite journal | vauthors = Weeks JC, Roberts WM, Leasure C, Suzuki BM, Robinson KJ, Currey H, Wangchuk P, Eichenberger RM, Saxton AD, Bird TD, Kraemer BC, Loukas A, Hawdon JM, Caffrey CR, Liachko NF | title = Sertraline, Paroxetine, and Chlorpromazine Are Rapidly Acting Anthelmintic Drugs Capable of Clinical Repurposing |journal=[[Scientific Reports]]| volume = 8 | issue = 1 | pages = 975 | date = January 2018 | pmid = 29343694 | doi = 10.1038/s41598-017-18457-w | publisher = [[Springer Science and Business Media LLC]] | pmc = 5772060 | bibcode = 2018NatSR...8..975W | s2cid = 205636792 }}
   }}
</ref>

Alberca ''et al.'', 2016 found that paroxetine acts as a [[trypanocide]] against ''[[Trypanosoma cruzi|T. cruzi]]''.<ref name="Chagas">
{{cite journal | vauthors = Ribeiro V, Dias N, Paiva T, Hagström-Bex L, Nitz N, Pratesi R, Hecht M | title = Current trends in the pharmacological management of Chagas disease |journal=[[International Journal for Parasitology: Drugs and Drug Resistance]]| volume = 12 | pages = 7–17 | date = April 2020 | pmid = 31862616 | pmc = 6928327 | doi = 10.1016/j.ijpddr.2019.11.004 | publisher = [[Elsevier BV]] | s2cid = 209435439 }}

This review cites this study.

{{cite journal | vauthors = Alberca LN, Sbaraglini ML, Balcazar D, Fraccaroli L, Carrillo C, Medeiros A, Benitez D, Comini M, Talevi A | title = Discovery of novel polyamine analogs with anti-protozoal activity by computer-guided drug repositioning |journal=[[Journal of Computer-Aided Molecular Design]]| volume = 30 | issue = 4 | pages = 305–321 | date = April 2016 | pmid = 26891837 | doi = 10.1007/s10822-016-9903-6 | publisher = [[Springer Science and Business Media LLC]] | bibcode = 2016JCAMD..30..305A | s2cid = 25677082 }}
</ref>

Alberca ''et al.'', 2016 finds a [[leishmanicide]] effect.<ref name="computerguided"/> Alberca finds that paroxetine produces [[cell death]] of the [[promastigote]]s of ''[[Leishmania infantum|L. infantum]]''.<ref name="computerguided"/> The [[mechanism of action]] remains unknown.<ref name="computerguided">

{{cite journal | vauthors = Andrade-Neto VV, Cunha-Junior EF, Dos Santos Faioes V, Pereira TM, Silva RL, Leon LL, Torres-Santos EC | title = Leishmaniasis treatment: update of possibilities for drug repurposing | journal = Frontiers in Bioscience | volume = 23 | issue = 5 | pages = 967–996 | date = January 2018 | pmid = 28930585 | doi = 10.2741/4629 | publisher = [[IMR Press]] }}<!-- Although a Beall's List predatory journal this review is cited by Santos et al., 2020, Carvalho et al., 2019 and Santana et al., 2021 et cetera. -->

This review cites this research.

{{cite journal | vauthors = Alberca LN, Sbaraglini ML, Balcazar D, Fraccaroli L, Carrillo C, Medeiros A, Benitez D, Comini M, Talevi A | title = Discovery of novel polyamine analogs with anti-protozoal activity by computer-guided drug repositioning | journal = Journal of Computer-Aided Molecular Design | volume = 30 | issue = 4 | pages = 305–321 | date = April 2016 | pmid = 26891837 | doi = 10.1007/s10822-016-9903-6 | publisher = [[Springer Science and Business Media LLC]] | bibcode = 2016JCAMD..30..305A | s2cid = 25677082 }}

</ref>

Various types of bacteria can break down paroxetine in the environment. These include, for example ''[[Pseudomonas|Pseudomonas sp.]]'', ''[[Bosea (bacterium)|Bosea sp.]]'', ''[[Shewanella|Shewanella sp.]], Species of [[Chitinophagaceae]] and ''[[Acinetobacter|Acinetobacter sp.]]<ref>{{Cite book |url=https://onlinelibrary.wiley.com/doi/book/10.1002/9781119678304 |title=Assessing the Microbiological Health of Ecosystems |date=19 December 2022 |publisher=Wiley |isbn=978-1-119-67832-8 | veditors = Hurst CJ |edition=1st |doi=10.1002/9781119678304}}</ref><ref>{{Cite journal | vauthors = Fernandes JP, Duarte P, Almeida CM, Carvalho MF, Mucha AP |date=August 2020 |title=Potential of bacterial consortia obtained from different environments for bioremediation of paroxetine and bezafibrate |journal=Journal of Environmental Chemical Engineering |volume=8 |issue=4 |pages=103881 |doi=10.1016/j.jece.2020.103881}}</ref>