Editing Infectious mononucleosis (section)

==Prognosis==
Serious [[complication (medicine)|complications]] are uncommon, occurring in less than 5% of cases:<ref>{{cite journal |author = Jensen, Hal B |date=June 2000 |title = Acute complications of Epstein-Barr virus infectious mononucleosis |journal = Current Opinion in Pediatrics |volume = 12 |issue = 3 |pages = 263–268 |issn = 1040-8703 |pmid = 10836164 |doi = 10.1097/00008480-200006000-00016 |s2cid=20566820 }}</ref><ref>{{cite journal |author = Aghenta A |date=May 2008 |title = Symptomatic atrial fibrillation with infectious mononucleosis |journal = Canadian Family Physician |volume = 54 |issue = 5 |pages = 695–696 |pmc = 2377232 |pmid = 18474702 |last2 = Osowo |first2 = A |last3 = Thomas |first3 = J}}</ref>
* [[Central nervous system|CNS]] complications include [[meningitis]], [[encephalitis]], [[hemiplegia]], [[Guillain–Barré syndrome]], and [[transverse myelitis]]. Prior infectious mononucleosis has been linked to the development of [[multiple sclerosis]].<ref name="pmid20824132">{{cite journal | vauthors = Handel AE, Williamson AJ, Disanto G, Handunnetthi L, Giovannoni G, Ramagopalan SV | title = An updated meta-analysis of risk of multiple sclerosis following infectious mononucleosis | journal = PLOS ONE | volume = 5 | issue = 9 | pages = e12496| date = September 2010 | pmid = 20824132 | pmc = 2931696 | doi = 10.1371/journal.pone.0012496  | bibcode = 2010PLoSO...512496H | doi-access = free }}</ref>
* [[Hematology|Hematologic]]: [[Autoimmune hemolytic anemia|Hemolytic anemia]] (direct [[Coombs test]] is positive) and various [[cytopenia]]s, and bleeding (caused by [[thrombocytopenia]]) can occur.<ref name="Mayo_Textbook"/>
* Mild [[jaundice]]
* [[Hepatitis]] with the Epstein–Barr virus is rare.
* Upper airway obstruction from [[Palatine tonsil#Tonsillar hypertrophy|tonsillar hypertrophy]] is rare.
* [[Fulminant]] disease course of [[immunodeficiency|immunocompromised]] people are rare.
* [[Splenic rupture]] is rare.
* [[Myocarditis]] and [[pericarditis]] are rare.
* [[Postural orthostatic tachycardia syndrome]]
* [[Myalgic encephalomyelitis/chronic fatigue syndrome]]
* [[Cancers]] associated with the Epstein–Barr virus include [[Burkitt's lymphoma]], [[Hodgkin's lymphoma]] and [[lymphomas]] in general as well as [[Nasopharyngeal carcinoma|nasopharyngeal]] and [[gastric carcinoma]].<ref>{{Cite journal|title = The role of Epstein-Barr virus in cancer.|date = November 2006|journal = Expert Opinion on Biological Therapy|last1 = Pattle|first1 = SB|pmid = 17049016|doi = 10.1517/14712598.6.11.1193|last2 = Farrell|first2 = PJ|volume=6|issue=11|pages=1193–205|s2cid = 36546018}}</ref>
* [[Hemophagocytic lymphohistiocytosis]]<ref name="pmid29358936">{{cite journal | vauthors = Marsh RA | title = Epstein–Barr Virus and Hemophagocytic Lymphohistiocytosis | journal = Frontiers in Immunology | volume = 8 | pages = 1902 | date  = 2017 | pmid = 29358936 | pmc = 5766650 | doi = 10.3389/fimmu.2017.01902 | doi-access = free }}</ref>

Once the acute symptoms of an initial infection disappear, they often do not return. But once infected, the person carries the virus for the rest of their life. The virus typically lives dormant in B lymphocytes. Independent infections of mononucleosis may be contracted multiple times, regardless of whether the person is already carrying the virus dormant. Periodically, the virus can reactivate, during which time the person is again infectious, but usually without any symptoms of illness.<ref name=CDC2014Eb/> Usually, a person with IM has few, if any, further symptoms or problems from the latent B lymphocyte infection. However, in susceptible hosts under the appropriate environmental stressors, the virus can reactivate and cause vague physical symptoms (or may be subclinical), and during this phase, the virus can spread to others.<ref name=CDC2014Eb/><ref>{{cite journal |vauthors=Sitki-Green D, Covington M, Raab-Traub N |title= Compartmentalization and Transmission of Multiple Epstein-Barr Virus Strains in Asymptomatic Carriers |journal= Journal of Virology |date=February 2003 |volume= 77 |issue= 3 |pages= 1840–1847 |doi= 10.1128/JVI.77.3.1840-1847.2003 |pmid= 12525618 |pmc= 140987  }}</ref><ref>{{cite journal |vauthors=Hadinoto V, Shapiro M, Greenough TC, Sullivan JL, Luzuriaga K, Thorley-Lawson DA  |title= On the dynamics of acute EBV infection and the pathogenesis of infectious mononucleosis |journal= Blood |date= February 1, 2008 |volume= 111 |issue= 3|pages= 1420–1427|doi= 10.1182/blood-2007-06-093278 |pmid= 17991806 |pmc= 2214734 }}</ref>