Editing High-performance liquid chromatography (section)

=== Manufacturing ===
HPLC has many applications in both laboratory and clinical science. It is a common technique used in pharmaceutical development, as it is a dependable way to obtain and ensure product purity.<ref>{{cite journal  |title=Practical aspects of fast reversed-phase high-performance liquid chromatography using 3 μm particle packed columns and monolithic columns in pharmaceutical development and production working under current good manufacturing practice |last1=Gerber |first1=Frederic |date=May 2004 |journal=Journal of Chromatography |volume=1036 |issue=2 |pages=127–33 |doi=10.1016/j.chroma.2004.02.056 |pmid=15146913 }}</ref> While HPLC can produce extremely high quality (pure) products, it is not always the primary method used in the production of bulk drug materials.<ref>{{cite journal |title=Analytical techniques in pharmaceutical analysis: A review |journal=Arabian Journal of Chemistry |volume=10 |pages=S1409–S1421 |doi=10.1016/j.arabjc.2013.04.016 |first1=Masoom Raza |last1=Siddiqui |first2=Zeid A. |last2=AlOthman |first3=Nafisur |last3=Rahman|year=2013 |doi-access=free }}</ref> According to the European pharmacopoeia, HPLC is used in only 15.5% of syntheses.<ref>''The European Pharmacopoeia'', 2002. fourth ed., Council of Europe, Strasbourg.</ref> However, it plays a role in 44% of syntheses in the United States pharmacopoeia.<ref>''United States Pharmacopoeia'', 2004. 27th ed. The USP Convention Inc., Rockville, MD.</ref> This could possibly be due to differences in monetary and time constraints, as HPLC on a large scale can be an expensive technique. An increase in specificity, precision, and accuracy that occurs with HPLC unfortunately corresponds to an increase in cost.