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=== Diabetes === Cellular uptake of glucose occurs in response to insulin signals, and glucose is subsequently broken down through glycolysis, lowering blood sugar levels. However, insulin resistance or low insulin levels seen in diabetes result in hyperglycemia, where glucose levels in the blood rise and glucose is not properly taken up by cells. Hepatocytes further contribute to this hyperglycemia through [[gluconeogenesis]]. Glycolysis in hepatocytes controls hepatic glucose production, and when glucose is overproduced by the liver without having a means of being broken down by the body, hyperglycemia results.<ref>{{Cite journal|date=2012-08-01|title=Glycolysis in the control of blood glucose homeostasis|journal=Acta Pharmaceutica Sinica B|language=en|volume=2|issue=4|pages=358β367|doi=10.1016/j.apsb.2012.06.002|issn=2211-3835| vauthors = Guo X, Li H, Xu H, Woo S, Dong H, Lu F, Lange AJ, Wu C |doi-access=free}}</ref>
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