Editing Enzyme (section)

====Irreversible====
An [[irreversible inhibitor]] permanently inactivates the enzyme, usually by forming a [[covalent bond]] to the protein.<ref>{{cite journal | vauthors = Strelow JM | title = A Perspective on the Kinetics of Covalent and Irreversible Inhibition | journal = SLAS Discovery | volume = 22 | issue = 1 | pages = 3–20 | date = January 2017 | pmid = 27703080 | doi = 10.1177/1087057116671509 | doi-access = free }}</ref> [[Penicillin]]<ref>{{cite journal | vauthors = Fisher JF, Meroueh SO, Mobashery S | title = Bacterial resistance to beta-lactam antibiotics: compelling opportunism, compelling opportunity | journal = Chemical Reviews | volume = 105 | issue = 2 | pages = 395–424 | date = February 2005 | pmid = 15700950 | doi = 10.1021/cr030102i }}</ref> and [[aspirin]]<ref name="Johnson">{{cite journal | vauthors = Johnson DS, Weerapana E, Cravatt BF | title = Strategies for discovering and derisking covalent, irreversible enzyme inhibitors | journal = Future Medicinal Chemistry | volume = 2 | issue = 6 | pages = 949–964 | date = June 2010 | pmid = 20640225 | pmc = 2904065 | doi = 10.4155/fmc.10.21 }}</ref> are common drugs that act in this manner.