Editing Ayahuasca (section)

== Pharmacology ==
{{Main article|N,N-Dimethyltryptamine|Monoamine oxidase inhibitor}}

=== Harmala alkaloids ===
{{Main article|Harmala alkaloid}}
[[File:Harmine structure.svg|class=skin-invert-image|right|thumb|Molecular structure of [[harmine]]]]
[[File:Harmaline structure.svg|class=skin-invert-image|right|thumb|Molecular structure of [[harmaline]]]]
[[File:Tetrahydroharmine structure.svg|class=skin-invert-image|right|thumb|Molecular structure of [[tetrahydroharmine]]]]
[[Harmala alkaloid]]s are MAO-inhibiting [[beta-Carboline|''beta''-carboline]]s. The three most studied harmala alkaloids in the ''B. caapi'' vine are [[harmine]], [[harmaline]] and [[tetrahydroharmine]]. Harmine and harmaline are [[Monoamine oxidase inhibitor#Selectivity|selective]] and [[Monoamine oxidase inhibitor#Reversibility|reversible]] inhibitors of [[monoamine oxidase A]] (MAO-A), while tetrahydroharmine is a weak [[serotonin reuptake inhibitor]] (SRI).{{medical citation needed|date=July 2023}}

Individual [[polymorphism (biology)|polymorphisms]] of the [[CYP2D6|cytochrome P450-2D6 enzyme]], and more over the isolated indocine metabolite from the inhabitation of CPY134a, with a varied rate of gustation due to physiological factors affect the ability of individuals to metabolize harmine.<ref name="Callaway2005a">{{cite journal |last=Callaway |first=J. C. |title=Fast and Slow Metabolizers of ''Hoasca'' |journal=Journal of Psychoactive Drugs |issn=0279-1072 |oclc=7565359 |volume=37 |issue=2 |pages=157–61 |date=June 2005 |pmid=16149329 |doi=10.1080/02791072.2005.10399797 |s2cid=41427434 }}</ref>