Editing Zebrafish (section)

====Developmental genetics====
[[T-box]]es and [[homeobox]]es are vital in ''Danio'' similarly to other vertebrates.<ref name="Schier-Talbot-2005">{{cite journal |last1=Schier |first1=Alexander F. |last2=Talbot |first2=William S. |title=Molecular Genetics of Axis Formation in Zebrafish |journal=[[Annual Review of Genetics]] |publisher=[[Annual Reviews (publisher)|Annual Reviews]] |volume=39 |issue=1 |date=2005-12-01 |issn=0066-4197 |doi=10.1146/annurev.genet.37.110801.143752 |pages=561–613 |pmid=16285872}}</ref><ref name="Naiche-et-al-2005">{{cite journal |last1=Naiche |first1=L.A. |last2=Harrelson |first2=Zachary |last3=Kelly |first3=Robert G. |last4=Papaioannou |first4=Virginia E. |title=T-Box Genes in Vertebrate Development |journal=[[Annual Review of Genetics]] |publisher=[[Annual Reviews (publisher)|Annual Reviews]] |volume=39 |issue=1 |date=2005-12-01 |issn=0066-4197 |doi=10.1146/annurev.genet.39.073003.105925 |pages=219–239 |pmid=16285859}}</ref> The Bruce et al. team are known for this area, and in Bruce et al. 2003 & Bruce et al. 2005 uncover the role of two of these elements in [[oocyte]]s of this species.<ref name="Schier-Talbot-2005" /><ref name="Naiche-et-al-2005" /> By interfering via a [[dominance (genetics)|dominant]] nonfunctional [[allele]] and a [[morpholino]] they find the T-box transcription activator [[Eomesodermin]] and its target ''[[mtx2]]'' – a [[transcription factor]] – are vital to [[epiboly]].<ref name="Schier-Talbot-2005" /><ref name="Naiche-et-al-2005" /> (In Bruce et al. 2003 they failed to support the possibility that Eomesodermin behaves like [[Vegt (development)|Vegt]].<ref name="Schier-Talbot-2005" /> Neither they nor anyone else has been able to locate any [[mutation]] which – in the mother – will prevent initiation of the [[mesoderm]] or [[endoderm]] development processes in this species.)<ref name="Schier-Talbot-2005" />