Editing Valproate (section)

===Formulations===
{{Infobox drug
| drug_name = Sodium valproate
| verifiedrevid = 464404696
| image = Sodium-valproate-2D-skeletal.png
| image_class = skin-invert-image
| width = 250
| alt =
| image2 = Valproato Sódico.png
| alt2 =
| USAN = valproate sodium
<!-- Clinical data -->
| tradename =
| DailyMedID = Valproate sodium
<!-- Identifiers -->
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 1069-66-5
| PubChem = 16760703
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DBSALT001257
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 13428
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 5VOM6GYJ0D
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D00710
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI = 9925
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 433

| legal_US = Rx-only
| legal_US_comment = <ref>{{cite web | title=Valproate sodium injection | website=DailyMed | date=1 January 2021 | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=bcf57b31-4811-4104-82b3-46fb91a53ee0 | access-date=7 October 2022 | archive-date=8 October 2022 | archive-url=https://web.archive.org/web/20221008050729/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=bcf57b31-4811-4104-82b3-46fb91a53ee0 | url-status=live }}</ref><ref>{{cite web | title=Valproate sodium injection, solution | website=DailyMed | date=29 April 2021 | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c572ece7-03d3-4c2a-aeb5-61f2023b28ea | access-date=7 October 2022 | archive-date=9 October 2022 | archive-url=https://web.archive.org/web/20221009184059/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c572ece7-03d3-4c2a-aeb5-61f2023b28ea | url-status=live }}</ref><ref name="Depakote FDA label" /><ref name="Depakote ER FDA label" />

<!-- Chemical and physical data -->
| IUPAC_name = sodium 2-propylpentanoate
| C=8 | H=15 | Na=1 | O=2
| SMILES = CCCC(CCC)C(=O)[O-].[Na+]
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C8H16O2.Na/c1-3-5-7(6-4-2)8(9)10;/h7H,3-6H2,1-2H3,(H,9,10);/q;+1/p-1
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = AEQFSUDEHCCHBT-UHFFFAOYSA-M
}}
{{Infobox drug
| drug_name = Valproate semisodium
| imageL = Sodium valproate.svg
| image_classL = skin-invert-image
| widthL = 250
| altL =
| imageR = 2-propylpentanoic acid 200.svg
| image_classR = skin-invert-image
| widthR = 250
| altR =
| captionLR =
| USAN = divalproex sodium
<!-- Clinical data -->
| tradename = Depakote, others
| DailyMedID = Divalproex sodium

| legal_US = Rx-only
| legal_US_comment = <ref name="Depakote FDA label" /><ref name="Depakote ER FDA label" />

<!-- Identifiers -->
| CAS_number = 76584-70-8
| PubChem = 23663956
| DrugBank = DBSALT000185
| ChemSpiderID = 48337
| UNII = 644VL95AO6
| KEGG = D00304
| ChEBI = 4667
| ChEMBL = 2105613
| synonyms = semisodium valproate
<!-- Chemical and physical data -->
| IUPAC_name = sodium 2-propylpentanoate;2-propylpentanoic acid
| C=16 | H=31 | Na=1 | O=4
| SMILES = CCCC(CCC)C(=O)O.CCCC(CCC)C(=O)[O-].[Na+]
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/2C8H16O2.Na/c2*1-3-5-7(6-4-2)8(9)10;/h2*7H,3-6H2,1-2H3,(H,9,10);/q;;+1/p-1
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = MSRILKIQRXUYCT-UHFFFAOYSA-M
}}

[[File:Magnesium Valproate China.jpg|thumb|280px|[[Magnesium]] valproate [[extended release]] and common release tablets manufactured in China]]

Valproate exists in two main molecular variants: ''sodium valproate'' and ''valproic acid without sodium'' (often implied by simply ''valproate''). A mixture between these two is termed ''semisodium valproate''. It is unclear whether there is any difference in efficacy between these variants, except from the fact that about 10% more mass of ''sodium valproate'' is needed than ''valproic acid without sodium'' to compensate for the sodium itself.<ref>{{cite book |title=The Maudsley Prescribing Guidelines |edition=Tenth |vauthors=Taylor D, Paton C, Kapur S |publisher=CRC Press |year=2009 |isbn=978-0-203-09283-5 |url=https://books.google.com/books?id=pbvLBQAAQBAJ&pg=PA124 |page=124 |access-date=17 September 2017 |archive-date=14 January 2023 |archive-url=https://web.archive.org/web/20230114092530/https://books.google.com/books?id=pbvLBQAAQBAJ&pg=PA124 |url-status=live }}</ref> In USA, Europe and many countrie the three variantes of vaproate are sold: vaproic acid, sodium valproate and valproate semisodium also known as divalproex sodium, the latter is believed to have fewer gastrointestinal side-effects.<ref name = "Fisher_2003" /><ref>{{cite journal | vauthors = Zhang CQ, Li HY, Wan Y, Bai XY, Gan L, Wang J, Sun HB | title = Efficacy, Safety, and Retention Rate of Extended-Release Divalproex Versus Conventional Delayed-Release Divalproex: A Meta-Analysis of Controlled Clinical Trials | language = English | journal = Frontiers in Pharmacology | volume = 13 | pages = 811017 | date = 2022-04-05 | pmid = 35479307 | doi = 10.3389/fphar.2022.811017 | doi-access = free | pmc = 9037144 }}</ref> '''Divalproex sodium tablets are''' '''a formulation''' comprising valproate sodium and valproic acid in a 1:1 molar relationship.

'''Magnesium valproate''' is also available in [[China]].<ref name=dxy1>{{Cite web|title=丙戊酸镁片（湖南湘中）|url=https://drugs.dxy.cn/pc/drug/DkKGkIFX1S864petr70Ykg==|work=丁香园·用药助手|access-date=2025-03-23}}</ref><ref name=dxy2>{{Cite web|title=丙戊酸镁缓释片（神泰）|url=https://drugs.dxy.cn/pc/drug/5R1pjNO2rmYyYvMYYmjGuA==|work=丁香园·用药助手|access-date=2025-03-23}}</ref>