Editing Syphilis (section)

===Late infections===
For neurosyphilis, due to the poor penetration of benzathine penicillin into the [[central nervous system]], those affected are given large doses of [[Intravenous therapy|intravenous]] [[penicillin G]] for a minimum of 10 days.<ref name=Kent08/><ref name=ST10/> If a person is allergic to penicillin, ceftriaxone may be used or penicillin [[Desensitization_(medicine)|desensitization]] attempted.<ref name=Kent08/> Other late presentations may be treated with once-weekly intramuscular benzathine penicillin for three weeks.<ref name=Kent08/> Treatment at this stage solely limits further progression of the disease and has a limited effect on damage which has already occurred.<ref name=Kent08/> Serologic cure can be measured when the non-treponemal titers decline by a factor of 4 or more in 6–12 months in early syphilis or 12–24 months in late syphilis.<ref name=NEJM2020/>