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==== General ==== Orgasm, and sexual activity as a whole, are physical activities that can require exertion of many major bodily systems. A 1997 study in the ''[[BMJ]]'' based upon 918 men aged 45β59 found that after a ten-year follow-up, men who had fewer orgasms were twice as likely to die of any cause as those having two or more orgasms per week.<ref>{{cite journal |title = Sex and Death: Are They Related? Findings from the Caerphilly cohort study |journal = [[BMJ]] |volume = 1997 |issue = 315 |pages = 1641β4 |doi = 10.1136/bmj.315.7123.1641 |date = December 20, 1997 |first1 = George |last1 = Davey Smith |author-link1 = George Davey Smith |first2 = Stephen |last2 = Frenkel |first3 = John |last3 = Yarnell |pmid = 9448525 |pmc = 2128033 }}</ref> A follow-up in 2001 which focused more specifically on [[cardiovascular]] health found that having sex three or more times per week was associated with a 50 percent reduction in the risk of heart attack or stroke. There is some research suggesting that greater resting heart rate variability is associated with orgasms through penile-vaginal intercourse without additional simultaneous clitoral stimulation.<ref name="Pappas" /> A small percentage of men have a disease called [[postorgasmic illness syndrome]] (POIS), which causes severe muscle pain throughout the body and other symptoms immediately following ejaculation. The symptoms last for up to a week.<ref name="Balon2005">{{cite book |title = Handbook of Sexual Dysfunction |publisher = Taylor & Francis |veditors = Balon R, Segraves RT |date = 2005 |isbn = 978-0-8247-5826-4 }}</ref><ref name="Wylie2015">{{cite book |url = https://books.google.com/books?id=oH64CAAAQBAJ&q=Post%20orgaasmic%20illness%20syndrome&pg=PA75 |title = ABC of Sexual Health |publisher = John Wiley & Sons |date = 2015 |page = 75 |isbn = 978-1-118-66556-5 |editor = Wylie KR |access-date = October 21, 2015 |archive-date = February 27, 2023 |archive-url = https://web.archive.org/web/20230227055206/https://books.google.com/books?id=oH64CAAAQBAJ&q=Post%20orgaasmic%20illness%20syndrome&pg=PA75 |url-status = live }}</ref><ref name="GARD">{{cite encyclopedia |title = Postorgasmic illness syndrome |encyclopedia = Genetic and Rare Diseases Information Center (GARD) |publisher = [[National Institutes of Health]] |access-date = July 30, 2015 |date = 2015 |url = https://rarediseases.info.nih.gov/gard/10809/postorgasmic-illness-syndrome/resources/1 |url-status = dead |archive-url = https://web.archive.org/web/20160305193016/https://rarediseases.info.nih.gov/gard/10809/postorgasmic-illness-syndrome/resources/1 |archive-date = March 5, 2016 |df = mdy-all }}</ref> Some doctors speculate that the frequency of POIS "in the population may be greater than has been reported in the academic literature",<ref name="Ashby2010">{{cite journal |title = Postorgasm illness syndrome--a spectrum of illnesses |vauthors = Ashby J, Goldmeier D |journal = J. Sex. Med. |date = May 2010 |volume = 7 |issue = 5 |pages = 1976β81 |doi = 10.1111/j.1743-6109.2010.01707.x |pmid = 20214722 |df = mdy-all }}</ref> and that many people with POIS are undiagnosed.<ref name="McMahon2014">{{cite journal |url = https://www.statusplus.net/issm/saopaulo2014/presentations/082.pdf |title = Post-Orgasmic Illness Syndrome |author = McMahon CG |journal = 16th World Meeting on Sexual Medicine |date = October 2014 |url-status = dead |archive-url = https://web.archive.org/web/20160304110554/https://www.statusplus.net/issm/saopaulo2014/presentations/082.pdf |archive-date = March 4, 2016 |df = mdy-all |accessdate = August 11, 2015 }}</ref>
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