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===Kidney injury and failure=== {{main|Acute kidney injury|Chronic kidney disease|Kidney failure}} Generally, humans can live normally with just one kidney, as one has more functioning renal tissue than is needed to survive. Only when the amount of functioning kidney tissue is greatly diminished does one develop [[chronic kidney disease]]. [[Renal replacement therapy]], in the form of [[Kidney dialysis|dialysis]] or [[kidney transplantation]], is indicated when the [[glomerular filtration rate]] has fallen very low or if the renal dysfunction leads to severe symptoms.<ref>{{cite journal | vauthors = Kalantar-Zadeh K, Jafar TH, Nitsch D, Neuen BL, Perkovic V | title = Chronic kidney disease | journal = Lancet | volume = 398 | issue = 10302 | pages = 786β802 | date = August 2021 | pmid = 34175022 | doi = 10.1016/S0140-6736(21)00519-5 | s2cid = 235631509 | url = https://researchonline.lshtm.ac.uk/id/eprint/4663580/1/Kalantar-Zadeh_etal_2021-Preserving-Kidney-Function-in-People.pdf | access-date = 2022-05-22 | archive-date = 2022-05-17 | archive-url = https://web.archive.org/web/20220517153016/https://researchonline.lshtm.ac.uk/id/eprint/4663580/1/Kalantar-Zadeh_etal_2021-Preserving-Kidney-Function-in-People.pdf | url-status = live }}</ref>
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