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=== Potential therapeutic effects === {{See also|Psychedelic therapy}}There are potential [[antidepressant]] and [[anxiolytic]] effects of ayahuasca.<ref name="Nunes dos Santos Osório Sanches pp. 195–205">{{cite journal | last1=Nunes | first1=Amanda A. | last2=dos Santos | first2=Rafael G. | last3=Osório | first3=Flávia L. | last4=Sanches | first4=Rafael F. | last5=Crippa | first5=José Alexandre S. | last6=Hallak | first6=Jaime E. C. | title=Effects of Ayahuasca and its Alkaloids on Drug Dependence: A Systematic Literature Review of Quantitative Studies in Animals and Humans | journal=Journal of Psychoactive Drugs | publisher=Informa UK Limited | volume=48 | issue=3 | date=2016-05-26 | issn=0279-1072 | doi=10.1080/02791072.2016.1188225 | pmid=27230395 | pages=195–205| hdl=11449/159021 | s2cid=5840140 | hdl-access=free }}</ref><ref name="Carbonaro Gatch 2016 pp. 74–88">{{cite journal | last1=Carbonaro | first1=Theresa M. | last2=Gatch | first2=Michael B. | title=Neuropharmacology of N,N-dimethyltryptamine | journal=Brain Research Bulletin | publisher=Elsevier BV | volume=126 | issue=Pt 1 | year=2016 | issn=0361-9230 | doi=10.1016/j.brainresbull.2016.04.016 | pmid=27126737 | pmc=5048497 | pages=74–88}}</ref><ref name="Frecska Bokor Winkelman p. ">{{cite journal | last1=Frecska | first1=Ede | last2=Bokor | first2=Petra | last3=Winkelman | first3=Michael | title=The Therapeutic Potentials of Ayahuasca: Possible Effects against Various Diseases of Civilization | journal=Frontiers in Pharmacology | publisher=Frontiers Media SA | volume=7 | pages=35 | date=2016-03-02 | issn=1663-9812 | doi=10.3389/fphar.2016.00035 | pmid=26973523 | pmc=4773875 | doi-access=free }}</ref> Ayahuasca has also been studied for the treatment of addictions and shown to be effective, with lower [[Addiction severity index|Addiction Severity Index]] scores seen in users of ayahuasca compared to controls.<ref name="FábregasGonzález2010">{{cite journal|last1=Fábregas|first1=Josep Maria|last2=González|first2=Débora|last3=Fondevila|first3=Sabela|last4=Cutchet|first4=Marta|last5=Fernández|first5=Xavier|last6=Barbosa|first6=Paulo César Ribeiro|last7=Alcázar-Córcoles|first7=Miguel Ángel|last8=Barbanoj|first8=Manel J.|last9=Riba|first9=Jordi|last10=Bouso|first10=José Carlos|title=Assessment of addiction severity among ritual users of ayahuasca|journal=Drug and Alcohol Dependence|volume=111|issue=3|year=2010|pages=257–261|issn=0376-8716|doi=10.1016/j.drugalcdep.2010.03.024|pmid=20554400}}</ref><ref name="LiesterPrickett2012">{{cite journal|last1=Liester|first1=Mitchell B.|last2=Prickett|first2=James I.|title=Hypotheses Regarding the Mechanisms of Ayahuasca in the Treatment of Addictions|journal=Journal of Psychoactive Drugs|volume=44|issue=3|year=2012|pages=200–208|issn=0279-1072|doi=10.1080/02791072.2012.704590|pmid=23061319|s2cid=32698157}}</ref><ref name="McKenna2004">{{cite journal|last1=McKenna|first1=Dennis J|title=Clinical investigations of the therapeutic potential of ayahuasca: rationale and regulatory challenges|journal=Pharmacology & Therapeutics|volume=102|issue=2|year=2004|pages=111–129|issn=0163-7258|doi=10.1016/j.pharmthera.2004.03.002|pmid=15163593}}</ref><ref name="Frecska Bokor Winkelman p. "/> Ayahuasca users have also been seen to consume less [[alcohol (drug)|alcohol]].<ref name="HarrisGurel2012">{{cite journal|last1=Harris|first1=Rachel|last2=Gurel|first2=Lee|title=A Study of Ayahuasca Use in North America|journal=Journal of Psychoactive Drugs|volume=44|issue=3|year=2012|pages=209–215|issn=0279-1072|doi=10.1080/02791072.2012.703100|pmid=23061320|s2cid=24580577}}</ref>
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