Editing Yellow fever (section)

==Research==
In the hamster model of yellow fever, early administration of the antiviral [[ribavirin]] is an effective treatment of many pathological features of the disease.<ref name="Sbrana_2004">{{cite journal | vauthors = Sbrana E, Xiao SY, Guzman H, Ye M, Travassos da Rosa AP, Tesh RB | title = Efficacy of post-exposure treatment of yellow fever with ribavirin in a hamster model of the disease | journal = The American Journal of Tropical Medicine and Hygiene | volume = 71 | issue = 3 | pages = 306–312 | date = September 2004 | pmid = 15381811 | doi = 10.4269/ajtmh.2004.71.306 | doi-access = free }}</ref> Ribavirin treatment during the first five days after virus infection improved survival rates, reduced tissue damage in the liver and [[spleen]], prevented hepatocellular [[steatosis]], and normalised levels of alanine aminotransferase, a liver damage marker. The mechanism of action of ribavirin in reducing liver pathology in Yellow fever virus infection may be similar to its activity in the treatment of [[hepatitis C]], a related virus.<ref name="Sbrana_2004" /> Because ribavirin had failed to improve survival in a virulent rhesus model of yellow fever infection, it had been previously discounted as a possible therapy.<ref name="Huggins_1989">{{cite journal | vauthors = Huggins JW | title = Prospects for treatment of viral hemorrhagic fevers with ribavirin, a broad-spectrum antiviral drug | journal = Reviews of Infectious Diseases | volume = 11 | issue = Suppl 4 | pages = S750–S761 | year = 1989 | pmid = 2546248 | doi = 10.1093/clinids/11.Supplement_4.S750 }}</ref> Infection was reduced in mosquitoes with the wMel strain of ''[[Wolbachia]]''.<ref>{{cite journal | vauthors = van den Hurk AF, Hall-Mendelin S, Pyke AT, Frentiu FD, McElroy K, Day A, Higgs S, O'Neill SL | display-authors = 6 | title = Impact of Wolbachia on infection with chikungunya and yellow fever viruses in the mosquito vector Aedes aegypti | journal = PLOS Neglected Tropical Diseases | volume = 6 | issue = 11 | pages = e1892 | year = 2012 | pmid = 23133693 | pmc = 3486898 | doi = 10.1371/journal.pntd.0001892 | doi-access = free }}</ref>

Yellow fever has been researched by several countries as a potential [[biological weapon]].<ref name=Endicott1998>{{cite book | vauthors = Endicott SL, Hageman E |title=The United States and Biological Warfare: Secrets from the Early Cold War and Korea |publisher=Indiana University Press |year=1998 |isbn=978-0-253-33472-5 |url=https://archive.org/details/unitedstatesbiol00endi }}</ref>