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===Low uric acid=== Low uric acid ([[hypouricemia]]) can have numerous causes. Low dietary [[zinc]] intakes cause lower uric acid levels. This effect can be even more pronounced in women taking oral contraceptive medication.<ref>{{cite journal |last1=Hess |first1=F. M. |last2=King |first2=J. C. |last3=Margen |first3=S. |title=Effect of low zinc intake and oral contraceptive agents on nitrogen utilization and clinical findings in young women |journal=The Journal of Nutrition |volume=107 |issue=12 |pages=2219β2227 |date=1 December 1977|pmid=925768 |doi=10.1093/jn/107.12.2219}}</ref> [[Sevelamer]], a drug indicated for prevention of [[hyperphosphataemia]] in people with [[chronic kidney failure]], can significantly reduce serum uric acid.<ref>{{cite journal |last1=Garg |first1=J. P. |last2=Chasan-Taber |first2=S. |last3=Blair |first3=A. |display-authors=etal |title=Effects of sevelamer and calcium-based phosphate binders on uric acid concentrations in patients undergoing hemodialysis: a randomized clinical trial |journal=Arthritis and Rheumatism |volume=52 |issue=1 |pages=290β295 |date=January 2005 |pmid=15641045 |doi=10.1002/art.20781|doi-access=free }}</ref> ====Multiple sclerosis==== [[Meta-analysis]] of 10 case-control studies found that the serum uric acid levels of patients with [[multiple sclerosis]] were significantly lower compared to those of healthy controls, possibly indicating a diagnostic [[biomarker]] for multiple sclerosis.<ref>{{cite journal |last1=Wang |first1=L. |last2=Hu |first2=W. |last3=Wang |first3=J. |last4=Qian |first4=W. |last5=Xiao |first5=H. |year=2016 |title=Low serum uric acid levels in patients with multiple sclerosis and neuromyelitis optica: An updated meta-analysis |pmid=27645338 |journal=Multiple Sclerosis and Related Disorders |volume=9 |pages=17β22 |doi=10.1016/j.msard.2016.05.008}}</ref> ====Normalizing low uric acid==== Correcting low or deficient zinc levels can help elevate [[blood serum|serum]] uric acid.<ref>{{cite journal |last1=Umeki |first1=S. |last2=Ohga |first2=R. |last3=Konishi |first3=Y. |last4=Yasuda |first4=T. |last5=Morimoto |first5=K. |last6=Terao |first6=A. |title=Oral zinc therapy normalizes serum uric acid level in Wilson's disease patients |journal=The American Journal of the Medical Sciences |volume=292 |issue=5 |pages=289β292 |date=November 1986 |pmid=3777013 |doi=10.1097/00000441-198611000-00007|s2cid=39995735 |doi-access=free }}</ref>
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