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===Alteration of taste perception=== After using toothpaste, [[orange juice]] and other fruit juices are known to have an unpleasant taste if consumed shortly afterwards. [[Sodium dodecyl sulfate|Sodium lauryl sulfate]], used as a surfactant in toothpaste, alters taste perception. It can break down [[phospholipid]]s that inhibit taste receptors for sweetness, giving food a bitter taste. In contrast, apples are known to taste more pleasant after using toothpaste.<ref>{{Cite journal| vauthors = DeSimone JA, Heck GL, Bartoshuk LM |title=Surface active taste modifiers: a comparison of the physical and psychophysical properties of gymnemic acid and sodium lauryl sulfate|journal=[[Chemical Senses]]|year=1980|volume=5|pages=317β330|doi=10.1093/chemse/5.4.317|issue=4}}</ref> Distinguishing between the hypotheses that the bitter taste of orange juice results from stannous fluoride or from sodium lauryl sulfate is still an unresolved issue and it is thought that the [[menthol]] added for flavor may also take part in the alteration of taste perception when binding to lingual [[thermoreceptor|cold receptors]].{{citation needed|date=December 2014}}
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