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== Ancient DNA == ''S. enterica'' genomes have been reconstructed from up to 6,500 year old human remains across Western Eurasia, which provides evidence for geographic widespread infections with systemic ''S. enterica'' during prehistory, and a possible role of the Neolithization process in the evolution of host adaptation.<ref>{{cite journal | vauthors = Key FM, Posth C, Esquivel-Gomez LR, Hübler R, Spyrou MA, Neumann GU, Furtwängler A, Sabin S, Burri M, Wissgott A, Lankapalli AK, Vågene ÅJ, Meyer M, Nagel S, Tukhbatova R, Khokhlov A, Chizhevsky A, Hansen S, Belinsky AB, Kalmykov A, Kantorovich AR, Maslov VE, Stockhammer PW, Vai S, Zavattaro M, Riga A, Caramelli D, Skeates R, Beckett J, Gradoli MG, Steuri N, Hafner A, Ramstein M, Siebke I, Lösch S, Erdal YS, Alikhan NF, Zhou Z, Achtman M, Bos K, Reinhold S, Haak W, Kühnert D, Herbig A, Krause J | title = Emergence of human-adapted Salmonella enterica is linked to the Neolithization process | journal = Nature Ecology & Evolution | volume = 4 | issue = 3 | pages = 324–333 | date = March 2020 | pmid = 32094538 | pmc = 7186082 | doi = 10.1038/s41559-020-1106-9 | bibcode = 2020NatEE...4..324K }}</ref><ref>{{cite journal | vauthors = Zhou Z, Lundstrøm I, Tran-Dien A, Duchêne S, Alikhan NF, Sergeant MJ, Langridge G, Fotakis AK, Nair S, Stenøien HK, Hamre SS, Casjens S, Christophersen A, Quince C, Thomson NR, Weill FX, Ho SY, Gilbert MT, Achtman M | title = Pan-genome Analysis of Ancient and Modern Salmonella enterica Demonstrates Genomic Stability of the Invasive Para C Lineage for Millennia | journal = Current Biology | volume = 28 | issue = 15 | pages = 2420–2428.e10 | date = August 2018 | pmid = 30033331 | pmc = 6089836 | doi = 10.1016/j.cub.2018.05.058 | doi-access = free | bibcode = 2018CBio...28E2420Z }}</ref> Additional reconstructed genomes from colonial Mexico suggest ''S. enterica'' as the cause of ''[[cocoliztli]]'', an epidemic in 16th-century [[New Spain]].<ref>{{cite journal | vauthors = Vågene ÅJ, Herbig A, Campana MG, Robles García NM, Warinner C, Sabin S, Spyrou MA, Andrades Valtueña A, Huson D, Tuross N, Bos KI, Krause J | title = Salmonella enterica genomes from victims of a major sixteenth-century epidemic in Mexico | journal = Nature Ecology & Evolution | volume = 2 | issue = 3 | pages = 520–528 | date = March 2018 | pmid = 29335577 | doi = 10.1038/s41559-017-0446-6 | bibcode = 2018NatEE...2..520V | s2cid = 3358440 }}</ref>
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