Editing Quorum sensing (section)

====''[[Vibrio cholerae]]''====

''V. cholerae'' is a bacterial pathogen that causes [[cholera]], a disease associated with severe contagious diarrhea that affects millions of people worldwide.  ''V. cholerae'' is capable of strong communication between cells, and this process is referred to as quorum-sensing.<ref>{{cite journal |vauthors=Sajeevan A, Ramamurthy T, Solomon AP |title=Vibrio cholerae virulence and its suppression through the quorum-sensing system |journal=Crit Rev Microbiol |volume= 51|issue= 1|pages=22–43 |date=March 2024 |pmid=38441045 |doi=10.1080/1040841X.2024.2320823 |url=}}</ref><ref>{{cite journal |vauthors=Li Y, Yan J, Li J, Xue X, Wang Y, Cao B |title=A novel quorum sensing regulator LuxT contributes to the virulence of Vibrio cholerae |journal=Virulence |volume=14 |issue=1 |pages=2274640 |date=December 2023 |pmid=37908129 |pmc=10621291 |doi=10.1080/21505594.2023.2274640 |url=}}</ref>  In the small intestine, the absence of oxygen and exposure to host-produced [[bile acid|bile salts]], influence ''V. cholerae'' quorum sensing function and thus its pathogenicity.<ref>{{cite journal |vauthors=Mashruwala AA, Bassler BL |title=The Vibrio cholerae Quorum-Sensing Protein VqmA Integrates Cell Density, Environmental, and Host-Derived Cues into the Control of Virulence |journal=mBio |volume=11 |issue=4 |pages= |date=July 2020 |pmid=32723922 |pmc=7387800 |doi=10.1128/mBio.01572-20 |url=}}</ref>  Quorum sensing appears to contribute to natural [[genetic transformation]], a process that involves the uptake of ''V. cholerae'' extracellular DNA by ([[natural competence|competent]]) ''V. cholerae'' cells.<ref>{{cite journal |vauthors=Blokesch M |title=A quorum sensing-mediated switch contributes to natural transformation of Vibrio cholerae |journal=Mob Genet Elements |volume=2 |issue=5 |pages=224–227 |date=September 2012 |pmid=23446800 |doi=10.4161/mge.22284 |pmc=3575429 |url=}}</ref>