Editing Pseudoephedrine (section)

==History==
Pseudoephedrine, along with [[ephedrine]], occurs [[natural product|naturally]] in [[ephedra (plant)|ephedra]].<ref name="LaccourreyeWernerGiroud2015" /><ref name="AbourashedEl-AlfyKhan2003" /><ref name="Kalix1991">{{cite journal | vauthors = Kalix P | title = The pharmacology of psychoactive alkaloids from ephedra and catha | journal = J Ethnopharmacol | volume = 32 | issue = 1–3 | pages = 201–208 | date = April 1991 | pmid = 1881158 | doi = 10.1016/0378-8741(91)90119-x | url = }}</ref> This herb has been used for thousands of years in [[traditional Chinese medicine]].<ref name="LaccourreyeWernerGiroud2015" /><ref name="AbourashedEl-AlfyKhan2003" /><ref name="Kalix1991" /> Pseudoephedrine was first [[chemical isolate|isolated]] and characterized in 1889 by the German chemists [[Albert Ladenburg|Ladenburg]] and Oelschlägel, who used a sample that had been isolated from ''[[Ephedra vulgaris]]'' by the [[Merck Group|Merck pharmaceutical corporation]] of [[Darmstadt]], Germany.<ref name="AbourashedEl-AlfyKhan2003" /><ref name="ChenKao1926" /><ref name="LadenburgOelschlägel1889">{{cite journal |vauthors=Ladenburg A, Oelschlägel C |title=Ueber das "Pseudo-Ephedrin" |journal=Berichte der Deutschen Chemischen Gesellschaft |date=1889 |volume=22 |issue=2 |pages=1823–1827 |url=https://babel.hathitrust.org/cgi/pt?id=osu.32435060218039;view=1up;seq=115 |trans-title=On pseudo-ephedrine |language=de |doi=10.1002/cber.18890220225 |access-date=19 May 2019 |archive-date=8 March 2021 |archive-url=https://web.archive.org/web/20210308053907/https://babel.hathitrust.org/cgi/pt?id=osu.32435060218039;view=1up;seq=115 |url-status=live }}</ref> It was first [[chemical synthesis|synthesized]] in the 1920s in [[Japan]].<ref name="LaccourreyeWernerGiroud2015" /> Subsequently, pseudoephedrine was introduced for medical use as a decongestant.<ref name="LaccourreyeWernerGiroud2015" />