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==== Autoimmune hypoglycemia ==== [[Antibody|Antibodies]] can be formed against insulin, leading to [[Autoimmunity|autoimmune]] hypoglycemia.<ref name="Jameson_2018" /><ref name=":12">{{Cite journal |vauthors=Lupsa BC, Chong AY, Cochran EK, Soos MA, Semple RK, Gorden P |date=May 2009 |title=Autoimmune forms of hypoglycemia |journal=Medicine |language=en-US |volume=88 |issue=3 |pages=141β153 |doi=10.1097/MD.0b013e3181a5b42e |pmid=19440117 |s2cid=34429211 |doi-access=free}}</ref> [[Antibody|Antibodies]] are immune cells produced by the body, that normally attack bacteria and viruses, but sometimes can attack normal human cells, leading to an [[Autoimmune disease|autoimmune disorder]].<ref>{{Cite web |title=Antibody |url=https://www.genome.gov/genetics-glossary/Antibody |url-status=live |archive-url=https://web.archive.org/web/20201009141818/https://www.genome.gov/genetics-glossary/Antibody |archive-date=9 October 2020 |access-date=24 January 2022 |website=Genome.gov |language=en}}</ref> In autoimmune hypoglycemia, there are two possible mechanisms.<ref name="Jameson_2018" /><ref name=":12" /> In one instance, antibodies bind to insulin following its release associated with a meal, resulting in insulin being non-functional.<ref name="Jameson_2018" /><ref name=":12" /> At a later time, the antibodies fall off insulin, causing insulin to be functional again leading late hypoglycemia after a meal, called ''late postprandial hypoglycemia''.<ref name="Jameson_2018" /><ref name=":12" /> Another mechanism causing hypoglycemia is due to antibodies formed against insulin [[Receptor (biochemistry)|receptors]], called ''insulin receptor antibodies''.<ref name="Jameson_2018" /><ref name=":12" /> The antibodies attach to insulin receptors and prevent insulin breakdown, or degradation, leading to inappropriately high insulin levels and low glucose levels.<ref name="Jameson_2018" /><ref name=":12" />
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