Editing Fragile X syndrome (section)

==History==
In 1943, British neurologist [[James Purdon Martin]] and British geneticist [[Julia Bell]] described a pedigree of X-linked intellectual disability, without considering the [[macroorchidism]] (larger testicles).<ref>{{cite journal |author1=Martin JP |author2=Bell J | title = A Pedigree of Mental Defect Showing Sex-Linkage | journal = Journal of Neurology and Psychiatry | volume = 6 | issue = 3–4 | pages = 154–157 | date = July 1943 | pmid = 21611430 | pmc = 1090429 | doi = 10.1136/jnnp.6.3-4.154 }}</ref> In 1969, Herbert Lubs first sighted an unusual "marker X chromosome" in association with intellectual disability.<ref>{{cite journal | vauthors = Lubs, HA | title = A marker X chromosome | journal = American Journal of Human Genetics | volume = 21 | issue = 3 | pages = 231–244 | date = May 1969 | pmid = 5794013 | pmc = 1706424 }}</ref> In 1970, Frederick Hecht coined the term "fragile site". And, in 1985, Felix F. de la Cruz outlined extensively the physical, psychological, and cytogenetic characteristics of those with the condition in addition to prospects for therapy.<ref>{{cite journal |author=de la Cruz, FF | title = Fragile X syndrome | journal = American Journal of Mental Deficiency | volume = 90 | issue = 2 | pages = 119–123 | date = September 1985 | pmid = 3901755 }}</ref> Continued advocacy later won him an honour through the FRAXA Research Foundation in December 1998.<ref>{{cite web |url=http://www.fraxa.org/pdf/NEWS1999.pdf |title= FRAXA Member Update (three issues: Spring 1999, Summer 1999, Fall 1999) |access-date=2017-12-14 |type= newsletter |publisher= FRAXA Research Foundation |location= [[Newburyport, Massachusetts]] |url-status=live |archive-url=https://web.archive.org/web/20101215090310/http://fraxa.org/pdf/NEWS1999.pdf |archive-date=2010-12-15 }}</ref>