Editing Cystic fibrosis (section)

===Transplantation===
[[Lung transplantation]] may become necessary for individuals with CF as lung function and [[Exercise intolerance|exercise tolerance]] decline. Although single lung transplantation is possible in other diseases, individuals with CF must have both lungs replaced because the remaining lung might contain bacteria that could infect the transplanted lung. A pancreatic or liver transplant may be performed at the same time to alleviate liver disease and/or diabetes.<ref name="pmid16298663">{{cite journal | vauthors = Fridell JA, Vianna R, Kwo PY, Howenstine M, Sannuti A, Molleston JP, Pescovitz MD, Tector AJ | title = Simultaneous liver and pancreas transplantation in patients with cystic fibrosis | journal = Transplantation Proceedings | volume = 37 | issue = 8 | pages = 3567–3569 | date = October 2005 | pmid = 16298663 | doi = 10.1016/j.transproceed.2005.09.091 }}</ref> Lung transplantation is considered when lung function declines to the point where assistance from mechanical devices is required or someone's survival is threatened.<ref name="pmid16387803">{{cite journal | vauthors = Belkin RA, Henig NR, Singer LG, Chaparro C, Rubenstein RC, Xie SX, Yee JY, Kotloff RM, Lipson DA, Bunin GR | title = Risk factors for death of patients with cystic fibrosis awaiting lung transplantation | journal = American Journal of Respiratory and Critical Care Medicine | volume = 173 | issue = 6 | pages = 659–666 | date = March 2006 | pmid = 16387803 | pmc = 2662949 | doi = 10.1164/rccm.200410-1369OC }}</ref> According to [[Merck Manual of Diagnosis and Therapy|''Merck Manual'']], "bilateral lung transplantation for severe lung disease is becoming more routine and more successful with experience and improved techniques. Among adults with CF, median survival posttransplant is about 9 years."<ref name="Cystic Fibrosis - Pediatrics">{{Cite web|title=Cystic Fibrosis - Pediatrics|url=https://www.merckmanuals.com/professional/pediatrics/cystic-fibrosis-cf/cystic-fibrosis|access-date=12 August 2020|website=Merck Manuals Professional Edition|language=en-US}}</ref>