Editing Cerebral cortex (section)

===Layer organization===
[[File:Human Cortical Development.png|right|thumb|Human cortical development between 26 and 39 week gestational age]]
The [[laminar organization|layered structure]] of the mature cerebral cortex is formed during development. The first pyramidal neurons generated migrate out of the [[ventricular zone]] and [[subventricular zone]], together with [[reelin]]-producing [[Cajal–Retzius cell|Cajal–Retzius neurons]], from the '''preplate'''. Next, a cohort of neurons migrating into the middle of the preplate divides this transient layer into the superficial '''marginal zone''', which will become layer I of the mature neocortex, and the [[subplate]],<ref>{{cite journal | vauthors = Kostovic I, Rakic P | title = Developmental history of the transient subplate zone in the visual and somatosensory cortex of the macaque monkey and human brain | journal = The Journal of Comparative Neurology | volume = 297 | issue = 3 | pages = 441–470 | date = July 1990 | pmid = 2398142 | doi = 10.1002/cne.902970309 | s2cid = 21371568 }}</ref> forming a middle layer called the '''cortical plate'''. These cells will form the deep layers of the mature cortex, layers five and six. Later born neurons migrate radially into the cortical plate past the deep layer neurons, and become the upper layers (two to four). Thus, the layers of the cortex are created in an inside-out order.<ref>{{cite journal | vauthors = Rakic P | title = Neurons in rhesus monkey visual cortex: systematic relation between time of origin and eventual disposition | journal = Science | volume = 183 | issue = 4123 | pages = 425–427 | date = February 1974 | pmid = 4203022 | doi = 10.1126/science.183.4123.425 | s2cid = 10881759 | bibcode = 1974Sci...183..425R }}</ref> The only exception to this inside-out sequence of [[neurogenesis]] occurs in the layer I of [[primate]]s, in which, in contrast to [[rodent]]s, neurogenesis continues throughout the entire period of [[corticogenesis]].<ref>{{cite journal | vauthors = Zecevic N, Rakic P | title = Development of layer I neurons in the primate cerebral cortex | journal = The Journal of Neuroscience | volume = 21 | issue = 15 | pages = 5607–5619 | date = August 2001 | pmid = 11466432 | pmc = 6762645 | doi = 10.1523/JNEUROSCI.21-15-05607.2001 }}</ref>