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===Addiction to melange=== Reverend Mothers are dependent on [[Melange (fictional drug)|melange]] to give them their abilities. Any person who consumes melange regularly becomes addicted to it and requires it for survival; however, one who has gone through the agony has a far greater need. Though the effects of melange are highly favorable, including vastly increased lifespan and mental powers, withdrawal results in death. Melange is expensive and thus is a continual drain on the Sisterhood's wealth; the most significant threat to the Bene Gesserit is the potential loss of their supply. Paul Atreides and then his son Leto II assert control over the Bene Gesserit and keep them in check by grasping control of the planet Arrakis and the spice supply in a show of [[Hydraulic empire|hydraulic despotism]].
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