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===Antidepressant-induced mania=== Another possible problem with antidepressants is the chance of antidepressant-induced [[mania]] or [[hypomania]] in people with or without a diagnosis of [[bipolar disorder]]. Many cases of bipolar depression are very similar to those of unipolar depression. Therefore, the person can be misdiagnosed with unipolar depression and be given antidepressants. Studies have shown that antidepressant-induced mania can occur in 20β40% of people with bipolar disorder.<ref>{{cite journal|vauthors=Goldberg JF, Truman CJ|title=Antidepressant-induced mania: An overview of current controversies|journal=Bipolar Disorders|volume=5|issue=6|pages=407β20|year=2003|pmid=14636364|doi=10.1046/j.1399-5618.2003.00067.x}}</ref> For bipolar depression, antidepressants (most frequently SSRIs) can exacerbate or trigger symptoms of hypomania and mania.<ref name="pmid9387089">{{cite journal|author=Benazzi F|title=Antidepressant-associated hypomania in outpatient depression: a 203-case study in private practice|journal=J Affect Disord|volume=46|issue=1|pages=73β7|year=1997|pmid=9387089|doi=10.1016/S0165-0327(97)00082-7}}</ref> [[Bupropion]] has been associated with a lower risk of mood switch than other antidepressants.<ref name="pmid37119556">{{cite journal|vauthors=Barbuti M, Menculini G, Verdolini N, Pacchiarotti I, Kotzalidis GD, Tortorella A, Vieta E, Perugi G|title=A systematic review of manic/hypomanic and depressive switches in patients with bipolar disorder in naturalistic settings: The role of antidepressant and antipsychotic drugs|journal=Eur Neuropsychopharmacol|volume=73|pages=1β15|date=April 2023|pmid=37119556|doi=10.1016/j.euroneuro.2023.04.013|s2cid=258334982|hdl=2445/210406|hdl-access=free}}</ref>
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